Prevotellaceae ⇒ Paraprevotella {10000833} Record Keys Parent:Prevotellaceae Definition:Paraprevotella Details Initialisation date:[ ] Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:Trypsin-degrading Notes: [ ]Shared Reference Notes [1.1] [#Behcet’s Disease] [#Butyrate, #Lactate, #Lipopolysaccharide] - These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and Paraprevotella was observed in the BD-recipient group. [1.2] [#Covid-19] - Paraprevotella colonization inhibits lethal infection with murine hepatitis virus-2, a mouse coronavirus that is dependent on trypsin and trypsin-like proteases for entry into host cells [#IG A] - Paraprevotella strains isolated from the faecal microbiome of healthy human donors are potent trypsin-degrading commensals. Mechanistically, Paraprevotella recruit trypsin to the bacterial surface through type IX secretion system-dependent polysaccharide-anchoring proteins to promote trypsin autolysis. - Paraprevotella colonization protects IgA from trypsin degradation and enhances the effectiveness of oral vaccines against Citrobacter rodentium. [1.3] [#Chronic fatigue syndrome] [#Ruminococcaceae] - genus Paraprevotella and Ruminococcaceae_UCG_014 were positively associated with ME/CFS risk. [1.4] - #Vogt-Koyanagi-Harada syndrome (VKH) > In this uveitis syndrome, a study demonstrated heightened levels of gram-negative bacteria, eg, #Bacteroides and Paraprevotella, in patients’ stools with a decrease in #Butyrate-producing bacteria. [1.5] [#Cognitive impairment] [#Bacteroides-Prevotella group] - Families including #Bacteroidaceae, #Rikenellaceae, along with genera including Paraprevotella, Ruminococcustques group, #Bacteroides, #Dialister, Paraprevotella, and RuminococcaceaeUCG003 had a protective effect on cognition. [1.6] [#Schizophrenia] [#Genome] - Paraprevotella and #Catabacter were identified to have a strong correlation with the above four SCZ genes [1.7] [#Diabetes Type 2] - #Streptococcus and #Eggerthella were relatively more abundant than in prediabetic fecal samples. - #Bacteroides, #Phascolarctobacterium, #Parabacteroides, and Paraprevotella were more abundant in prediabetic fecal samples.References Notes[ ]
