Disease ⇒ Graves' disease ⇒ Graves’ orbitopathy {40000399} Record Keys Type:Disease Parent:Graves’ disease Definition:Graves’ orbitopathy Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10057889 MedDra Level:llt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Graves’ disease] - when patients were hyperthyroid and TRAB positive, #Actinobacteria were significantly increased and Bacteroidetes significantly decreased in GD/GO compared with HC. - #Bacteroides displayed positive and negative correlations with TSH and FT4 respectively and was also significantly associated with #Smoking in GO, #Smoking is a risk factor for GO but not GD. [#Graves’ disease] - presence of certain bacteria (#Clostridiales) at diagnosis correlated with the persistence of TRAB 200 + days after commencing anti-thyroid drug treatment. [1.2] [#Prevotella copri] - In patients with GO, who had high levels of TRAb, the abundance of the family #Prevotellaceae, and P. copri species, in particular, in the gut microbial community was correlated with TRAb levels. [1.3] - #Klebsiella pneumoniae was deemed the potentially pathogenic bacteria of GO, and its abundance was positively correlated with disease severity.References Notes[ ]
