Natural Med. Cond. ⇒ Menopause {40000565} Record Keys Type:Natural Med. Cond. Parent:[ ] Definition:Menopause Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Postmenopausal women trended toward lower gut microbiome diversity and altered overall composition compared to premenopausal women. - Differentially abundant taxa for post- versus premenopausal women included Bacteroides sp. strain Ga6A1, Prevotella marshii, and Sutterella wadsworthensis (enriched in postmenopause) and Escherichia coli-Shigella spp., Oscillibacter sp. strain KLE1745, Akkermansia muciniphila, Clostridium lactatifermentans, Parabacteroides johnsonii, and Veillonella seminalis (depleted in postmenopause); [1.2] [#Breast cancer] [#Soybean] - soy #Isoflavone intake is associated with a modest reduction in menopausal hot flushes and decreased breast and #Prostate cancer risk. [1.3] - Treatment with #Lactobacillus intestinalis YT2 significantly alleviates symptoms of menopause, such as increased fat content, decreased bone density, increased pain sensitivity, depressive-like behavior, and cognitive impairments [1.4] [#Postmenopausal] [#High Fat Diet] - ovariectomy led to greater gastrointestinal permeability and inflammation of the gut and metabolic organs, and that a high-fat diet exacerbated these phenotypes. - Ovariectomy also led to alteration of the gut microbiome, including greater fecal β-glucuronidase activity. - differential changes in the gut microbiome only occurred when fed a low-fat diet, not the high-fat diet. - Gnotobiotic mice that received the gut microbiome from ovariectomized mice fed the low-fat diet had greater weight gain and hepatic gene expression related to metabolic dysfunction and inflammation than those that received intact sham control-associated microbiome. References Notes[ ]
