Bacteroides ⇒ Bacteroides ovatus {10000788}

Shared Reference Notes

• [1.1] 
  - Inositol, a carbocyclic sugar abundant in eukaryotes, forms the basis for diverse phosphorylated secondary messenger inositol phosphates and #Inositol Lipids. - #Inositol Lipids are ubiquitous in eukaryotes and have finely tuned roles in cellular signalling and membrane homoeostasis. - In Bacteria, however, inositol lipid production is relatively rare. - #Bacteroides thetaiotaomicron (BT) was reported to produce #Inositol Lipids and sphingolipids (and Bacteroides ovatus).
• [1.2] [#Acute lymphoblastic leukemia] [#Pseudomonas aurantiaca, #Roseburia intestinalis, #Roseburia inulinivorans] 
  - #Children with ALL exhibit reduced relative abundance of both #Butyrate-producing species (#Roseburia faecis, R. intestinalis, R. inulinivorans, #Anaerostipes hardus, #Faecalibacterium prausnitzii, #Eubacterium ramulus) and #Acetate-producing species (#Prevotella maculosa, P. aurantiaca, #Bacteroides uniformis, B. ovatus)
• [#Acute lymphoblastic leukemia] [#Bacteroides uniformis, #Bacteroides vulgatus] [#Cesarean section] - #Children with ALL at the time of diagnosis were reported to have reduced relative abundance of B. vulgatus, B. ovatus and B. uniformis; that is, immunomodulatory bacterial species whose transmission from mother to child is disrupted by C-section
• [#Bacteroides uniformis] [#Infants] - #Bacteroides species (for example, B. ovatus and B. uniformis), whose successful and timely colonization is determined by the mode of delivery, can have a profound impact on stool IgA levels during infancy.
• [1.3] [#Diabetes Type 2] [#Paraclostridium bifermentans] 
  - Various gut bacterial species, like #Bacteroides thetaiotaomicron, B. ovatus, #Clostridium limosum, and C. bifermentans metabolize amino acid #Tryptophan (Trp) to #Indole. - It helps to secret glucagon-like-peptide-1 (GLP-1), which has an important role to increase insulin secretion and inhibit glucagon secretion.
• [1.4] [#Blautia obeum] [#Immune checkpoint inhibitor] 
  - The most distinctive species associated with ICI non-response were B. obeum and B. ovatus.
• [1.5] [#Bacteroides cellulosilyticus, #Bacteroides thetaiotaomicron] 
  - Genes involved in #Glycogen storage were significantly upregulated in B. ovatus, B. cellulosyliticus and B. thetaiotaomicron, during intestinal colonization in mice.
• [1.6] [#4-ethylphenol, #4-ethylphenylsulfate] 
  - A subset of the required enzymes (e.g., hydroxycinnamate reductase enzymes (HCRs), #Tyrosine #Ammonia-lyase (TALs)) are encoded within the genomes of many microbes (e.g., #Clostridium aerotolerans, #Clostridium xylanolyticum and Bacteroides ovatus) > increase 4EP
• [1.7] [#4-ethylphenylsulfate] 
  - B. ovatus is a primary producer of a precursor to 4EPS and increased #Anxiety behaviors in mice.
• [#Bacteroides uniformis, #Bacteroides vulgatus] [#Short Chain Fatty Acid] - the size of the left nucleus accumbens were dominated by Bacteroides species, especially B. vulgatus, B. uniformis, and B. ovatus. B. ovatus has been shown to produce a number of neuroactive compounds including SCFAs and #Neurotransmitters such as γ-aminobutyric acid (#GABA)
• [1.8] [#Major depressive disorder] [#Bacteroides thetaiotaomicron] 
  - MDD > An enzyme (α-L-arabinofuranosidase) in the GH51 family, encoded by two dominant Bacteroides (B. ovatus V975 and B. thetaiotaomicron VPI-5482)
• [#Major depressive disorder] [#Bacteroides thetaiotaomicron] - #Bacteroides, especially #Bacteroides thetaiotaomicron and #Bacteroides ovatus, dedicate about 6% of their genomes to encode these two CAZymes. - These results suggesting that alternations of #Bacteroides species was a hallmark of MDD,

References Notes