Chemotherapy {50000156}

Shared Reference Notes

• [1.1] 
  - During the chemotherapeutic treatment of Patients with acute myeloid leukemia , the number of bacteria in fecal samples was 100-fold lower than that in healthy control samples, which resulted in a lower diversity of intestinal microbiota. - Bacteroides species, Clostridium cluster XIVa, Faecalibacterium prausnitzii, and Bifidobacterium species decreased 3000–6000-fold in samples during treatment. - Daunorubicin inhibited the growth of Clostridium species, Streptococcus mitis, Bifidobacterium animalis, and Lactobacillus acidophilus but not the growth of enterococci or E. coli. - Decrease in the phylum Firmicutes distributed within Clostridium cluster XIVa, Roseburia, Lachnospiraceae, and Coprococcus and a reduction in lactobacilli and enterococci in the mucosa of mice exposed to CTX.
• [1.2] [#Cancer, #Neutropenia] 
  - Transferring gut microbiota from patients with neutropenic #Fever to irradiated mice promoted the development of subsequent #Fever. - An excess of mucin-degrading #Akkermansia bacteria found in the transferred microbiomes of febrile patients, as well as in nontransplanted but irradiated or chemotherapy-treated mice that reduced their food intake, resulted in a compromised intestinal barrier in mice that could be circumvented by administration of propionate.
• [1.3] [#Fusobacterium nucleatum] [#Antibiotic Therapy] 
  - mice experiments have shown that antibiotic use suppresses F. nucleatum significantly increases chemotherapy efficacy
• [1.4] 
  - enterotoxigenic #Bacteroides fragilis (ETBF) was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant chemotherapy. - ETBF, albeit at low biomass, secreted the toxic protein #BFT-1 to promote #Breast cancer cell stemness and chemoresistance. - #BFT-1 directly bound to NOD1 and stabilized NOD1 protein.

References Notes