Disease ⇒ Intermittent Hypoxia {40000653} Record Keys Type:Disease Parent:[ ] Definition:Intermittent Hypoxia Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Obstructive sleep apnea-hypopnea syndrome] - gut microbiome changes associated with IH can independently cause #Sleep disturbances in mice. - The #Sleep disorders observed in mice resemble the excessive daytime sleepiness commonly found in individuals with OSA. - In chronic intermittent hypoxia (CIH) mice, beneficial genera like #Clostridium, #Akkermansia, and #Bacteroides reduced in presence while pathogenic genera like #Desulfovibrio increased. - IH mice exhibited increased levels of #Desulfovibrio, a bacterium that adversely impacts the intestinal barrier, contributing to the disruption of the intestinal barrier. [#Lipopolysaccharide] - plasma concentrations of LPS in mice exposed to IH remained significantly increased even after 6 weeks of normoxic recovery. - gut dysbiosis still persisted after exposure to normoxia. - IH affects the arterial partial pressure of #Oxygen, which could result in a hypoxia/reoxygenation pattern within the gut [1.2] [#Deoxycholic acid, #Lithocholic acid] - #Ruminococcaceae families perform the subsequent 7α-dehydroxylation of CA and CDCA to respectively generate DCA and LCA, has been associated with intermittent hypoxia and hypercapnia conditionsReferences Notes[ ]
