Disease ⇒ Neuromyelitis optica {40000338} Record Keys Type:Disease Parent:[ ] Definition:Neuromyelitis optica Details Initialisation date:[ ] Other Terms:NMO Meta Information MedDra ID:10077875 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: Neuromyelitis optica (NMO) is a demyelinating disease that mainly affects the optic nerve and spinal cord. Unlike in the case of MS, the target antigen generating autoimmunity is known in some patients with NMO.Shared Reference Notes [1.1] [#Short Chain Fatty Acid] - lower faecal SCFA levels in these patients, and a negative correlation between #Acetate and #Butyrate levels and disease severity. - Neuromylitis optica Patients with anti-AQP4 antibodies have been shown to develop cross-reactivity to a homologous peptide sequence within a protein of #Clostridium perfringens, a bacterium found to be more abundant in patients with NMO and able to generate a Th17 response, which is involved in autoimmune diseases - patients with NMO spectrum disorders > significant increase in the abundance of #Streptococcus, which is corrected with immunomodulatory drugs. References Notes[ ]
