Microbiome & Chronic Diseases

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High-fibre diet {51111189}

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High-fibre diet
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- Foods high in fiber include artichokes, asparagus, onions, beans, and berries.

Shared Notes

  • [1.8
    - Long-term intake of fibers from fruit > protective against the development of CD, but not of UC
  • [1.1
    - High fiber diet > Prevotella copri > improve glucose and insulin tolerance.
  • - Fiber-rich diets > maintain a healthy, diverse microbiome > beneficial metabolites such as short-chain fatty acids (SCFAs) > promote mucus and antimicrobial peptides production > maintain intestinal barrier integrity > robust immunity.
  • [1.2
    - Carbohydrate (fiber) consumption > increased Prevotella
  • [1.5
    - Dietary fiber > competitive advantage to Bifidobacteria
  • [1.3
    - Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy > reduced incidence of asthma in offspring which persists into adulthood.
    - Reduced dietary fiber intake > reduced serum acetate levels in pregnant women > increased frequency of coughing/wheezing during the child’s first year of life.
    - During pregnancy > SCFA (such as acetate) > cross the placenta and affect the expression of fetal lung genes, such as NPPA, > encodes ANP (a molecule related to epithelial biology and immune regulation).
  • [1.9
    - The high-fiber diet > increased microbiome-encoded glycan-degrading carbohydrate active enzymes (CAZymes) despite stable microbial community diversity > Cytokine response score (primary outcome) unchanged,.
    - Three distinct immunological trajectories in high-fiber consumers corresponded > to baseline microbiota diversity.
  • [1.7
    - Higher Prevotella-to-Bacteroides ratios > human > lose significantly more weight on a high-fiber diet, particularly individuals with low salivary amylase levels
  • - Higher dietary fiber > improved progression-free survival in 128 patients on immune checkpoint blockade (ICB) treatment, with the most pronounced benefit observed in patients with sufficient dietary fiber intake and no probiotic use.
  • [1.6
    - Dietary fiber intake was inversely associated with risk of dementia.
    - The inverse association was more evident for soluble fiber intake and was confined to dementia without a history of stroke.
  • [1.4
    - Epidemiological evidence indicates that children suffering from allergies have lower levels of dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model of AD-like skin inflammation,
    - a fermentable fibre-rich diet alleviates systemic allergen sensitization and disease severity.
    - particularly butyrate, which strengthens skin barrier function by altering mitochondrial metabolism of epidermal keratinocytes and the production of key structural components.
  • [1.13
    - Of particular relevance to the gut microbiome are fermentable fibers, also referred to as microbiota-accessible carbohydrates (MACs)
    - Fiber provides growth substrates for microbes that inhibit mucus-glycan metabolism, preventing gut-mucus depletion, encroachment of bacteria into the mucus layer, and downstream inflammation andinfections.
    - Gut microbes are responsible for biotransformation of phytochemicals via processes such as demethylation, ring cleavage, and dehydroxylation, which can increase their bioavailability, absorption, and antioxidative and immunomodulatory effects.
    - Fruits and vegetables provide up to 8 g of dietary fiber per serving and contain a high diversity of fibers, including pectins, inulin, cellulose, xyloglucans, raffinose, and stachyose.
    - These fibers elicit both microbiome-independent (e.g., delayed macronutrient absorption) and microbiome-dependent (e.g., SCFA-mediated attenuation of insulin resistance) physiological effects
  • - vegetables rich in inulin increased Bifidobacterium levels, promoted satiety, and reduced body weight

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