High-fibre diet {51111189}
Factor: | High-fibre diet |
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Queue: | [ ] |
Initialisation date: | 2021-04-19 |
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Specification: | |
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Type: | Diet |
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Host: | [ ] |
Zone: | [ ] |
Notes:
- Foods high in fiber include artichokes, asparagus, onions, beans, and berries.
Shared Notes
- [1.8]
- Long-term intake of fibers from fruit > protective against the development of CD, but not of UC - [1.1]
- High fiber diet > Prevotella copri > improve glucose and insulin tolerance. - - Fiber-rich diets > maintain a healthy, diverse microbiome > beneficial metabolites such as short-chain fatty acids (SCFAs) > promote mucus and antimicrobial peptides production > maintain intestinal barrier integrity > robust immunity.
- [1.2]
- Carbohydrate (fiber) consumption > increased Prevotella - [1.5]
- Dietary fiber > competitive advantage to Bifidobacteria - [1.3]
- Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy > reduced incidence of asthma in offspring which persists into adulthood.
- Reduced dietary fiber intake > reduced serum acetate levels in pregnant women > increased frequency of coughing/wheezing during the child’s first year of life.
- During pregnancy > SCFA (such as acetate) > cross the placenta and affect the expression of fetal lung genes, such as NPPA, > encodes ANP (a molecule related to epithelial biology and immune regulation). - [1.9]
- The high-fiber diet > increased microbiome-encoded glycan-degrading carbohydrate active enzymes (CAZymes) despite stable microbial community diversity > Cytokine response score (primary outcome) unchanged,.
- Three distinct immunological trajectories in high-fiber consumers corresponded > to baseline microbiota diversity. - [1.7]
- Higher Prevotella-to-Bacteroides ratios > human > lose significantly more weight on a high-fiber diet, particularly individuals with low salivary amylase levels - - Higher dietary fiber > improved progression-free survival in 128 patients on immune checkpoint blockade (ICB) treatment, with the most pronounced benefit observed in patients with sufficient dietary fiber intake and no probiotic use.
- [1.6]
- Dietary fiber intake was inversely associated with risk of dementia.
- The inverse association was more evident for soluble fiber intake and was confined to dementia without a history of stroke. - [1.4]
- Epidemiological evidence indicates that children suffering from allergies have lower levels of dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model of AD-like skin inflammation,
- a fermentable fibre-rich diet alleviates systemic allergen sensitization and disease severity.
- particularly butyrate, which strengthens skin barrier function by altering mitochondrial metabolism of epidermal keratinocytes and the production of key structural components. - [1.13]
- Of particular relevance to the gut microbiome are fermentable fibers, also referred to as microbiota-accessible carbohydrates (MACs)
- Fiber provides growth substrates for microbes that inhibit mucus-glycan metabolism, preventing gut-mucus depletion, encroachment of bacteria into the mucus layer, and downstream inflammation andinfections.
- Gut microbes are responsible for biotransformation of phytochemicals via processes such as demethylation, ring cleavage, and dehydroxylation, which can increase their bioavailability, absorption, and antioxidative and immunomodulatory effects.
- Fruits and vegetables provide up to 8 g of dietary fiber per serving and contain a high diversity of fibers, including pectins, inulin, cellulose, xyloglucans, raffinose, and stachyose.
- These fibers elicit both microbiome-independent (e.g., delayed macronutrient absorption) and microbiome-dependent (e.g., SCFA-mediated attenuation of insulin resistance) physiological effects - - vegetables rich in inulin increased Bifidobacterium levels, promoted satiety, and reduced body weight