Berberine {90000242} Record Keys Parent:[ ] Definition:Berberine Queue:[ ] Details Initialisation date:2022-01-12 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#CVD, #Dyslipidemia, #Postprandial lipidemia, #Diabetes Type 2] [#Probiotic] - Prob+BBR superior to BBR or Prob alone in improving postprandial total cholesterol (pTC) and low-density lipoprotein cholesterol (pLDLc) levels with decrement of multiple species of postprandial lipidomic metabolites after 3 months follow-up. - This effect was linked to the changes of fecal #Bifidobacterium breve level responding to BBR alone or Prob+BBR treatment. - Four fadD genes encoding long-chain acyl-CoA synthetase > identified in the genome of this B. breve strain, and transcriptionally activated by BBR. - The activation of fadD by BBR could enhance FFA import and mobilization in B. breve and diliminish the intraluminal lipids for absorption to mediate the effect of Prob+BBR on PL. [1.2] [#Clostridioides difficile] - BBR has direct inhibitory effects on #Bacteria such as #Clostridium difficile, #Actinobacillus, and #Bacillus subtilis [#Anorexia nervosa] - BBR > decrease in #Ruminococcus gnavus and Ruminococcus schinkii and an increase in #Bacteroides were observed in normal mice after treatment with BBR - BBR is a natural compound with direct antibacterial effects [#Bile Acids] - BBR can cause an increase in serum BA, total BA, and primary BA content - BBR (32 μg/mL) can inhibit the growth of #Candida albicans by inhibiting biofilm formation [#Christensenellaceae, #Prevotellaceae] [#Short Chain Fatty Acid] - Berberine > the relative abundances of #Parabacteroides, Prevotellaceae_UCG-001, and Prevotellaceae_NK3B31_group increased, the relative abundance of Christensenellaceae_R-7_group decreased, and cecal SCFA levels (#Acetic acid and #Propionic acid) were reduced. [#Diabetes Type 2] [#High Fat Diet] - The increase in #Fasting plasma #Glucose, #Fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) caused by HFD feeding decreased after BBR treatmen [1.3] - Berberine > The intestinal immune pathway of Immunoglobulin A production was activated, and the expression of TNFSF13B (Tumor necrosis factor superfamily 13b, encoding B lymphocyte Stimulator [BLyS]), the representative gene of this pathway, and the genes encoding its receptors, (interleukin-10 and transforming growth factor beta) were significantly upregulated. [#Colon adenomas, #Colorectal cancer] - The abundance of fecal #Veillonella parvula (V. parvula) decreased significantly after Berberine administration and increased through the development from CRA to CRC. [#Veillonella parvula] - Animal experiments revealed that V. parvula promoted colorectal carcinogenesis and increased B lymphocyte Stimulator levels, while Berberine reversed this effect.References Notes[ ]
