Negibacteria ⇒ Fusobacteria {10001031}

Shared Reference Notes

• [1.1] [#Oral cancer] 
  - The abundance of dominant genera such as Fusobacteria increased with cancer development, the abundance of Haemophilus, Streptococcus, Actinomyces, and Porphyromonas decreased.
• [1.2] 
  - Five bacterial phyla including #Firmicutes, #Bacteroidetes, #Actinobacteria, #Proteobacteria, and Fusobacteria can participate in #Tryptophan metabolism, being those belonging to the #Clostridium, #Burkholderia, #Streptomyces, #Pseudomonas or #Bacillus genera the most important modulators
• [1.3] [#Gastric carcinoma] 
  - Gastric mucosal biopsies from intra-epithelial neoplasia and adenocarcinoma patients have shown a higher abundance of #Actinobacteria, #Bacteroides, #Firmicutes, and Fusobacteria
• [1.4] 
  - #Fusobacterium, which belongs to the Fusobacteria phylum, was also identified as one of the potential #Butyrate producers, which could modulate the gut microbiota and even modify anti-inflammatory, tumor-fighting, and metabolic pathways
• [1.5] 
  - A complete #Riboflavin operon is present in all Baceteroidetes and Fusobacteria, as well as in 92% of #Proteobacteria - half of the #Firmicutes are predicted to be #Riboflavin producers
• [1.6] 
  - fusobacterial adhesin/invasin FadA, which binds to #E-cadherin on carcinoma cells and activates β-catenin signaling. This pathway results in enhanced transcriptional activity of Wnt, activation of pro-inflammatory cytokines, oncogenes, and stimulation of #Cancer cells proliferation
• [1.7] [#Glycogen] 
  - Specific genes involved in carbohydrate metabolism, including glgB (glucan branching enzyme), were highly expressed by Fusobacteria.
• [1.8] 
  - enrichment of #Actinobacteria in patients with #Ankylosing spondylitis, and depletion of Fusobacteria and #Verrucomicrobia
• [1.9] 
  - #Sulfur-containing amino acids can be fermented by Enterobacteria, #Enterococci, Peptostreptococci, Fusobacteria, and #Eubacteria

References Notes