Bacteroides ⇒ Bacteroides vulgatus {10000146}

Shared Reference Notes

• [1.1] [#Ulcerative Colitis] 
  - Elastase activity directly correlated with known proteolytic taxa, such as #Bacteroides vulgatus and high elastase activity was confirmed in Bacteroides isolates from fecal samples. - Mice colonized with or born from pre-UC colonized dams developed higher fecal proteolytic activity and an inflammatory immune tone compared with HC colonized mice.
• [1.2] [#Polycystic ovary syndrome] 
  - A dysbiotic gut microbiome from women with PCOS or Bacteroides vulgatus (positively associated with PCOS in antibiotic-treated mice) transplanted into mice induced a PCOS-like phenotype (HA, disrupted estrous cycle, decreased ovulation, ovarian cysts, and a decrease in fertility.) - Higher testosterone levels are linked with changes in the overall composition of the gut microbial community. It is unclear whether testosterone exerts an effect on gut microbes directly and/or indirectly through actions in androgen target tissues.
• [1.3] [#Crohn’s disease] 
  - Bacteroides vulgatus is both directly associated with Th17 immunity and has a higher abundance in active CD relative to non-IBD controls. - The increase of Bacteroides vulgatus abundance in active CD can induce more Th17 cells that in turn might worsen IBD inflammation.
• [#Inflamatory bowel disease] - Seven bacterial species correlated with expression levels of Th17 effector cytokines, IL-17A and IL-17F. - The seven associated species include #Ruminococcus gnavus, #Escherichia coli, #Lachnospiraceae bacterium, #Clostridium hathewayi, #Bacteroides faecis, Bacteroides vulgatus, and #Akkermansia muciniphila. All of the species were positively associated with IL-17A/ IL-17F except #Akkermansia muciniphila, suggesting these species are proinflammatory, while #Akkermansia muciniphila is anti-inflammatory.
• [1.4] [#Diabetes Type 2] 
  - TIIDM > low levels of #Roseburia inulinivorans, #Eubacterium eligens , and Bacteroides vulgatus, - All these bacteria > increase following the “good” diet and > decrease following the “bad” diet.
• [1.5] 
  - the tested consortium was composed of four butyrate producers (#Faecalibacterium prausnitzii, #Butyricicoccus pullicaecorum, #Roseburia inulinivorans, and #Anaerostipes caccae) and five propionate producers (#Roseburia inulinivorans, #Akkermansia muciniphila, Bacteroides vulgatus, #Veillonella parvula, and #Blautia obeum)
• [1.6] [#Ulcerative Colitis] [#Primary bile acids, #Secondary bile acids] 
  - colonic CD displayed a disease-severity-related association with Bacteroides vulgatus. - Compared to colonic CD, ileal CD profiles displayed increased primary and secondary bile acid levels and concomitant shifts in taxa with noted sensitivities such as #Faecalibacterium prausnitzii or affinities for bile acid-rich environments, including #Gammaproteobacteria and #Blautia sp.
• [1.7] [#Chronic fatigue syndrome, #Irritable bowel syndrome] [#Alistipes putredinis, #Anaerotruncus colihominis, #Clostridium asparagiforme, #Coprococcus catus, #Dorea formicigenerans, #Faecalibacterium prausnitzii] 
  - Nine bacterial species were selected to predict ME/CFS + IBS: F. prausnitzii, Bacteroides vulgatus, A. putredinis, C. catus, #Anaerostipes caccae, D. formicigenerans, A. colihominis and C. asparagiforme.
• [1.8] [#Anorexia nervosa] 
  - in AN > Serum #Leucine mediated the influence of B. vulgatus counts on #Glucose homeostasis.
• [1.9] [#Actinomyces massiliensis] 
  - #Athletes from 16 different sports > dominated by a single or a combination of five species, namely #Eubacterium rectale, Polynucleobacter necessarius, #Faecalibacterium prausnitzii, Bacteroides vulgatus, and #Gordonibacter massiliensis. - Species such as #Bifidobacterium animalis, #Lactobacillus acidophilus, #Prevotella intermedia, and F. prausnitzii were associated with #Athletes participating in high dynamic component sports.
• [#Acute lymphoblastic leukemia] [#Bacteroides ovatus, #Bacteroides uniformis] [#Cesarean section] - #Children with ALL at the time of diagnosis were reported to have reduced relative abundance of B. vulgatus, B. ovatus and B. uniformis; that is, immunomodulatory bacterial species whose transmission from mother to child is disrupted by C-section
• [1.11] [#carrot-derived rhamnogalacturonan I] [#Carrot] 
  - cRG-I supplementation (already at an HED of 0.3 g/d) lowered interpersonal compositional differences due to the selective stimulation of taxa that were consistently present among human adults, including OTUs related to #Bacteroides dorei/vulgatus and #Bifidobacterium longum (suspected keystone species), #Bacteroides thetaiotaomicron, #Bifidobacterium adolescentis and #Butyrate-producing taxa such as #Blautia sp., #Anaerobutyricum hallii, and #Faecalibacterium prausnitzii.
• [1.12] [#Bacteroides stercoris, #Prevotella copri] 
  - P. copri, B. stercoris, and B. vulgatus to be highly abundant in the baseline microbiomes of individuals in whom lifestyle interventions had only a minor impact on the microbial community’s structure. - They are highly stable in the absence of interventions suggesting their potential as biomarkers for microbiome stratification.
• [1.13] 
  - Some specific gut microbes, such as #Akkermansia muciniphila, Bacteroides vulgatus, #Bacteroides dorei, and #Roseburia intestinalis are associated with the development of #Atherosclerosis.
• [1.14] [#Polycystic ovary syndrome] 
  - Bacteroides vulgatus has also been shown to be enriched in the gut microbiota of PCOS patients and induced PCOS-like symptoms in a murine model by altering bile acid metabolism and host immune response
• [1.15] [#Bacteroides uniformis] 
  - #Bacteroidin-2 (produced by #Bacteroides cellulosilyticus) targeted several different classes including nearly all #Bacteroidia in our panel (except for B. uniformis and B. vulgatus), as well as #Akkermansia muciniphila, and #Eubacterium rectale of the #Verrucomicrobiae and #Clostridia classes, respectively.
• [1.16] [#Osteoporosis, #Postmenopausal osteoporosis] 
  - several individual bacterial species (especially B. vulgatus) were significantly associated with bone mineral density (BMD) in ethnically distinct populations. - serum VA levels were positively associated with L1-L4 BMD; - B. vulgatus was negatively associated with serum VA levels and may causally suppress VA levels, presumably by inhibiting growth of VA-producing bacteria within the gut. - Serum #Valeric acid (VA), a microbiota derived metabolite, was positively associated with BMD and causally downregulated by B. vulgatus. - Ovariectomized mice fed B. vulgatus demonstrated increased bone resorption and poorer bone micro-structure, while those fed VA demonstrated reduced bone resorption and better bone micro-structure. - NO effect of B. vulgatus on the sham-operated groups of mice, which indicates that the B. vulgatus may have distinct effects in eugonadic mice and estrogen deficient mice.
• [1.17] [#Bacteroides ovatus, #Bacteroides uniformis] [#Short Chain Fatty Acid] 
  - the size of the left nucleus accumbens were dominated by Bacteroides species, especially B. vulgatus, B. uniformis, and B. ovatus. B. ovatus has been shown to produce a number of neuroactive compounds including SCFAs and #Neurotransmitters such as γ-aminobutyric acid (#GABA)
• [1.18] [#Celiac Disease] 
  - B. vulgatus-A2 strain may exert a protective role by acting on the gut epithelium with a coordinated action involving protection against loss of barrier function, cell death and pro-inflammatory cytokine production. - this unique strain isolated from controls and not present in cases had several mutations compared to the ATCC 8482 reference strain that affects its capacity to regulate metabolic pathways of the host related to inflammatory response and barrier function. - B. vulgatus-A2 CFS was able to ameliorate the gliadin-induced cell damage and increased epithelial permeability. - B. vulgatus-A2 strain protective effect against gluten > could act through miRNAs reprogramming in the celiac gut epithelium.

References Notes