Pectin {90000129} Record Keys Parent:[ ] Definition:Pectin Queue:[ ] Details Initialisation date:2021-02-02 Specification: - Pectin is a major component of plant cell wallsSource: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory Notes: [ ]Shared Reference Notes [1.1] [1.2] - The dietary fiber pectin is shown to prevent this intestinal inflammation through direct inhibition of TLR2 in a microbiota-independent manner. - Inhibition of TLR2 is determined by the number and distribution of methyl-esters of pectins. - The degree of methyl-esterification (DM) and the degree of blockiness (DB) of pectins determine attenuating efficacy on doxorubicin-induced #Intestinal mucositis. [1.3] [#Citrobacter rodentium] - Pectins > anti-inflammatory properties on intestinal immunity > direct interactions on Toll-like receptors (TLRs) in the small intestine or via stimulating microbiota-dependent effects in the large intestine. - Pectins> prevent C. rodentium induced colonic inflammation > lowering the C. rodentium load in the caecum independently of the DB. [1.4] [#High fibre diet] - Dietary fibre is comprised of both soluble and insoluble carbohydrates and includes pectin, cellulose, lignin, hemicellulose, #Arabinoxylan, nondigestible oligosaccharide #Inulin, #Oligofructose and #Resistant Starch. - #Apple pectin was three times more effective in promoting #Bacteroides growth and overall microflora diversity than #Inulin [#Clostridiales XIV] - pectin, which make up 35% of fruit fibre cell wall, increases #Butyrate-producing species such as Clostridium cluster XIV [1.5] - Some oligosaccharides are originated from a #Polysaccharide known as pectin > pectic oligosaccharide (POS)References Notes[ ]
