Listeriaceae ⇒ Listeria {10000777} Record Keys Parent:Listeriaceae Definition:Listeria Details Initialisation date:[ ] Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Listeria spp. target tumors through the intracellular infection of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), which migrate to the immunosuppressive TME. - The transported Listeria is then transmitted from MDSCs to #Cancer cells via a unique cell–cell spread mechanism. - The shrinkage of tumors by Listeria spp. involves the combination of the direct killing of #Cancer cells by Listeria infection and cytotoxic T cell response toward Listeria antigens. - Listeria spp. convert a subpopulation of Listeria-infected MDSCs into an immune-stimulating phenotype that produces interleukin-12 (IL-12), a cytokine linked with heightened T cell and NK cell responses. - Listeria spp. directly kill #Cancer cells by activating NADP (+) oxidase and increasing intracellular calcium levels, which trigger the production of reactive oxygen species (ROS) [1.2] - Other important #Firmicutes genera are Listeria, #Paenibacillus, #Staphylococcus, #Streptococcus, #Pediococcus, and #Leuconostoc. [1.3] [#Colorectal cancer] - #Akkermansia and #Bacteroides emerged as notable microbes enriched in yoCRC tumors as compared to Bacillus, #Staphylococcus, Listeria, #Enterococcus, #Pseudomonas, #Fusobacterium, and #Escherichia/#Shigella which have consistently been implicated with higher relative abundance in aoCRC tumorsReferences Notes[ ]
