Listeriaceae ⇒ Listeria {10000777}

Shared Reference Notes

• [1.1] 
  - Listeria spp. target tumors through the intracellular infection of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), which migrate to the immunosuppressive TME. - The transported Listeria is then transmitted from MDSCs to #Cancer cells via a unique cell–cell spread mechanism. - The shrinkage of tumors by Listeria spp. involves the combination of the direct killing of #Cancer cells by Listeria infection and cytotoxic T cell response toward Listeria antigens. - Listeria spp. convert a subpopulation of Listeria-infected MDSCs into an immune-stimulating phenotype that produces interleukin-12 (IL-12), a cytokine linked with heightened T cell and NK cell responses. - Listeria spp. directly kill #Cancer cells by activating NADP (+) oxidase and increasing intracellular calcium levels, which trigger the production of reactive oxygen species (ROS)
• [1.2] 
  - Other important #Firmicutes genera are Listeria, #Paenibacillus, #Staphylococcus, #Streptococcus, #Pediococcus, and #Leuconostoc.

References Notes