Quercetin {90000310}

Shared Reference Notes

• [1.1] [#Onion] 
• [1.2] [#CVD] 
  - quercetin, a flavonol from #Apple intake, also found in oregano, has been noted to extend preventative effects of cardiovascular disease in individuals at risk of the disease
• [1.3] [#Polyphenol-rich supplementation] 
  - Four dietary #Polyphenols (rutin, quercetin, chlorogenic acid, and #Caffeic acid) can reduce the ratio of #Firmicutes to #Bacteroides in in vitro gut microbiota experiments.
• [1.4] 
  - the level of quercetin consumption was negatively correlated with the abundance of #Sutterellaceae and #Oscillospiraceae spp. and positively correlated with the families #Fusobacteriaceae and #Enterobacteriaceae
• - Quercetin was also shown to inhibit #Obesity-induced hypothalamic inflammation by inhibiting microglia-mediated inflammatory responses, likely through mechanisms involving heme oxygenase induction.
• - quercetin, is also heavily processed by the gut microbiota. In an in vitro anaerobic fermentation model, the fecal microbiota was shown to deconjugate rutin, isoquercetin and a mixture of quercetin glucuronides through deglycosylation, ring fission and dehydroxylation reactions to produce the metabolites 3,4-dihydrophenylacetic acid and 3-hydroxyphenylacetic acid
• - quercetin suppressed cPLA2 phosphorylation, an activity that was shown to prevent microglia-induced neurotoxicity in differentiated SH-SY5Y neuroblast cells
• [1.5] 
  - Quercetin can be extracted from various plants including Moringa oleifera, Sophora Japonica L., berries, apples, and onions. - Quercetin exhibits unique biological characteristics including antibiotic, anti-oxidative, anti-inflammatory, immunomodulatory, and anti-fibrotic effects. - quercetin scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), inhibits lipid oxidation, and chelates iron, protecting cells against oxidative damages. - Quercetin absorption is the small intestine , about 5 to 10% of it undergoes complete absorption in the small intestine, whereas, about 90 to 95% of quercetin is absorbed in the colon.
• [1.6] 
  - As with quercetin, #Myricetin absorption rate may be low because its absorption might have been influenced by the type of glycosidic linkages.
• [1.7] [#Diabetes Type 2] 
  - Quercetin has also shown to abolish NLRP3 inflammasome activation in macrophages by upregulating Akt signaling, reducing insulin resistance in mice with particulate matter-induced metabolic disorder
• - several kinds of #Polyphenols have shown to improve mitochondrial function, namely through the activation of the key mitochondrial biogenesis’ PGC-1α, including #Ursolic acid , #Resveratrol, quercetin and #Olive #Hydroxytyrosol
• [1.8] [#Inflamatory bowel disease] [#Flavonoid] 
  - #Broccoli, #Kale, radish, and #Cabbage are flavonoids-rich with quercetin and cyanidin, and #Polyphenols like ferulic, sinapic, and caffeic acids for #Prebiotic, endothelial and epithelial barrier protection, antioxidant, anti-inflammatory and anti-adhesive potential to complement the effect of ITCs against IBD

References Notes