Microbiome & Chronic Diseases

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Quercetin {90000310}

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Shared Reference Notes

  • [1.1] [#Onion
  • [1.2] [#CVD
    - quercetin, a flavonol from #Apple intake, also found in oregano, has been noted to extend preventative effects of cardiovascular disease in individuals at risk of the disease
  • [1.3] [#Polyphenol-rich supplementation
    - Four dietary #Polyphenols (rutin, quercetin, chlorogenic acid, and #Caffeic acid) can reduce the ratio of #Firmicutes to #Bacteroides in in vitro gut microbiota experiments.
  • [1.4
    - the level of quercetin consumption was negatively correlated with the abundance of #Sutterellaceae and #Oscillospiraceae spp. and positively correlated with the families #Fusobacteriaceae and #Enterobacteriaceae
  • - Quercetin was also shown to inhibit #Obesity-induced hypothalamic inflammation by inhibiting microglia-mediated inflammatory responses, likely through mechanisms involving heme oxygenase induction.
  • - quercetin, is also heavily processed by the gut microbiota. In an in vitro anaerobic fermentation model, the fecal microbiota was shown to deconjugate rutin, isoquercetin and a mixture of quercetin glucuronides through deglycosylation, ring fission and dehydroxylation reactions to produce the metabolites 3,4-dihydrophenylacetic acid and 3-hydroxyphenylacetic acid
  • - quercetin suppressed cPLA2 phosphorylation, an activity that was shown to prevent microglia-induced neurotoxicity in differentiated SH-SY5Y neuroblast cells
  • [1.5
    - Quercetin can be extracted from various plants including Moringa oleifera, Sophora Japonica L., berries, apples, and onions. - Quercetin exhibits unique biological characteristics including antibiotic, anti-oxidative, anti-inflammatory, immunomodulatory, and anti-fibrotic effects. - quercetin scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), inhibits lipid oxidation, and chelates iron, protecting cells against oxidative damages. - Quercetin absorption is the small intestine , about 5 to 10% of it undergoes complete absorption in the small intestine, whereas, about 90 to 95% of quercetin is absorbed in the colon.
  • [1.6
    - As with quercetin, #Myricetin absorption rate may be low because its absorption might have been influenced by the type of glycosidic linkages.

References Notes

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