Disease ⇒ Tuberculosis {40000222}

Shared Reference Notes

• [1.1] 
• [1.2] [#Pulmonary tubercolosis] 
  - The PTB group showed the most unique microbiota by higher abundance of Bifidobacteriaceae, Bifidobacteriales, Coriobacteriaceae, Coriobacteriales, Actinobacteria, Caulobacteraceae, Phyllobacteriaceae, Rhizobiales, Burkholderiaceae, Burkholderiaceae. Inflammatory status in PTB patients may be associated with the increased abundance of Clostridia and decreased abundance of Prevotella. We found that the abundance of Solobacterium and Actinobacteria was higher in the patients.
• [1.3] [#Covid-19, #Influenza A, #Pneumonia] 
• [1.4] [#Akkermansia muciniphila, #Mycobacterium tuberculosis] [#Probiotic (A. muciniphila)] 
  - Oral treatment of A. muciniphila or A. muciniphila-mediated #Palmitoleic acid strongly inhibits tuberculosis infection through epigenetic inhibition of tumour necrosis factor in mice infected with Mycobacterium tuberculosis.
• [#Akkermansia muciniphila] - single-nucleotide polymorphism #rs2257167 ‘G’ allele of type I interferon receptor 1 (encoded by IFNAR1 in humans) contributes to stronger type I interferon signalling, impaired colonization and abundance of A. muciniphila, reduced #Palmitoleic acid production, higher levels of tumour necrosis factor, and more severe tuberculosis disease in humans and transgenic mice
• [1.5] [#Cancer] [#Mycobacterium tuberculosis] 
  - #Indole-3-propionic acid, an indole derivative, exhibits biological activities similar to those of indoles, such as affecting host susceptibility to Mycobacterium tuberculosis anticancer activity.
• [1.6] [#Diabetes Type 1, #Diabetes Type 2, #Pulmonary tubercolosis] 
  - the microbiota in latent TB infection group displayed a similar alpha-diversity but different beta-diversity, featuring decrease of Prevotella_9, Streptococcus, and Actinomyces and increase of Bacteroides, Alistipes, and Blautia at the genus level.
• [1.7] 
• [1.8] [#Pulmonary tubercolosis] 
  - The genera #Parabacteroides, #Bacteroides, #Lachnoclostridium, and #Fusobacterium were markedly enhanced in the PTB group, while #Roseburia, #Blautia, unidentified #Ruminococcaceae, #Bifidobacterium, #Romboutsia, and #Fusicatenibacter were enhanced in the HC group.
• [#Short Chain Fatty Acid] - TB infection reduced the SCFA production in feces which included significantly low levels of #Butyric acid, #Isobutyric acid, #Valeric acid, and #2-metylbutic acid. However, the levels of #Propionic acid and #Acetic acid were non-significantly reduced and elevated, respectively, in the TB group compared with HC.
• - #Prevotella, which is better equipped to consume plant-derived carbohydrates, was markedly depleted in TB patients, while the abundance of #Bacteroides was increased
• - #Prevotella and #Bifidobacterium were markedly reduced in TB patients.
• [#Enterobacteriaceae bacterium] - #Clostridium bolteae and an unclassified #Coprobacillus bacterium, were found enriched within the TB patients.

References Notes