Microbiome & Chronic Diseases

Evidence Based Medicine
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Sulfate {90000140}

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Shared Reference Notes

  • [1.1
    - high concentrations of H2S from sulfate-reducing bacteria in gut microbiota can adversely affect the bowel environment by increasing toxicity and lowering pH, contributing to the immune response and to inflammatory activation in the gut. - elevated abundance of sulfate-reducing bacteria from #Anaerostipes hadrus may contribute to gut barrier disruption and immune response activation in the gut, promoting IA seroconversion.
  • [#Diabetes Type 1] [#Lipopolysaccharide] - lipopolysaccharides biosynthesis in #Bacteroides MAGs (metagenome-assembled genomes) and sulfate reduction in #Anaerostipes MAGs as functional signatures of MAGs with positive IA-association (Islets autoantibody)
  • [1.2] [#Behcet’s Disease] [#Butyrate, #Lactate, #Lipopolysaccharide
    - These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
  • [1.3] [#Ceramides] [#Aging
    - Among metabolites that were positively associated with age, seven were common in all four groups (aconitic acid, #Choline, #Citrulline, #Cysteine, cystine, #kynurenine, and symmetric dimethylarginine (SDMA)) and 10 were common in three out of four groups (aspartic acid, asymmetric dimethylarginine (ADMA), butyrylcarnitine, ceramide d18:1/24:1, ceramide d18:1/25:0, ceramide d18:2/24:1, hippuric acid, homocysteine, methionine sulfoxide, and #p-cresol sulfate)

References Notes

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