Microbiome & Chronic Diseases

Evidence Based Medicine
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Sulfate {90000140}

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Shared Reference Notes

  • [1.3
    - lipopolysaccharides biosynthesis in Bacteroides MAGs (metagenome-assembled genomes) and sulfate reduction in Anaerostipes MAGs as functional signatures of MAGs with positive IA-association (Islets autoantibody)
  • - high concentrations of H2S from sulfate-reducing bacteria in gut microbiota can adversely affect the bowel environment by increasing toxicity and lowering pH, contributing to the immune response and to inflammatory activation in the gut.
    - elevated abundance of sulfate-reducing bacteria from Anaerostipes hadrus may contribute to gut barrier disruption and immune response activation in the gut, promoting IA seroconversion.
  • [1.2
    - These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, sulfate-reducing bacteria, and some opportunistic pathogens but lacked butyric acid-producing bacteria and methanogenic bacteria.
    - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation.
    - enrichment of Bilophila, Alistipes, and Paraprevotella was observed in the BD-recipient group.