Serine {90000600} Record Keys Parent:[ ] Definition:Serine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Alzheimer’s disease] - #Butyric acid-mediated acetylation of GSK3β at lysine 15 regulated its phosphorylation at serine, consequently impacting #Tau phosphorylation. [1.2] - #Staphylococcus aureus, a bacterial pathogen associated with itchy skin diseases, directly activates pruriceptor sensory neurons to drive itch. - Epicutaneous S. aureus exposure causes robust itch and scratch-induced damage. - S. aureus serine protease V8 as a critical mediator in evoking spontaneous itch and alloknesis. - V8 cleaves proteinase-activated receptor 1 (PAR1) on mouse and human sensory neurons. [1.3] - #Bacteroides spp. with serine palmitoyltransferase (SPT) gene have the ability to produce #Sphingolipids. [1.4] - oral bioavailability of #Butyrate can be increased by esterifying it to serine, an amino acid transporter that aids the escape of the resulting odourless and tasteless prodrug (O-butyryl-L-serine, which we named SerBut) from the gut, enhancing its systemic uptake. References Notes[ ]
