Eubacteriaceae ⇒ Eubacterium {10000157} Record Keys Parent:Eubacteriaceae Definition:Eubacterium Details Initialisation date:2020-09-06 LinksSource Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:Anti-inflammatory Notes: [ ]Shared Reference Notes [1.1] [#Bile Acids] - Butyrate producing bacteria such as Eubacterium spp. are capable of transforming primary BAs to secondary BAs such as: #Lithocholic acid and #Deoxycholic acid, which are potentially cytotoxic and have been linked to #Colorectal cancer and cholesterol GS formation. [1.2] [#Vegetarian diet] - Dominant species in vegetarians are #Ruminococcus, #Roseburia, and Eubacterium. [1.3] [#Infants, #Mother-infant] - Maternal gut strains transmitted after the first 3 months of life included members of the genera Eubacterium, #Roseburia, and #Blautia. [1.4] - #Proanthocyanidins are biotransformed by #Adlercreutzia equolifaciens JCM 14793T, Eubacterium sp. SDG-2, #Eggerthella lenta rK3 and #Eggerthella lenta CAT-1 and from the phylum actinomycetes, which belong to the phylum #Actinobacteria, through the cleavage of the C-ring and dihydroxylation reactions to produce (−)EGC, (−)-gallocatechin (GC), (±)EC and (±)-catechin (C) [1.5] [#Inflamatory bowel disease] [#Short Chain Fatty Acid] The first signs of aggravation of IBD are : - a loss of the main anti-inflammatory Short-Chain Fatty Acids (SCFAs) #Roseburia, Eubacterium, #Subdoligranumum, #Ruminococcus - an increase in pro-inflammatory pathogens #Proteus, #Finegoldia - an increase of other minor SCFA producers such as #Ezakiella, #Anaerococcus, #Megasphaera, #Anaeroglobus, #Fenollaria. - Further aggravation of clinical signs is significantly linked to the subsequent loss of these minor SCFAs species and to an increase in other proinflammatory Proteobacteria such as Klebsiella, Pseudomonas, Salmonella, Acinetobacter, Hafnia and proinflammatory Firmicutes such as Staphylococcus, Enterococcus, Streptococcus. [1.6] - Butyrylated high-amylose maize resistant starch decreased red meat-derived pro-mutagenic adduct O6-methyl-2-deoxyguanosine and related CRC risk. - Certain #Butyrate-producing bacteria such as #Clostridium, #Ruminococcus, #Faecalibacterium spp., Eubacterium spp., and #Roseburia, were found to decrease in relative frequency in CRC patients. - #Butyrate inhibited the growth of CRC cells and induced their apoptosis in vitro at pharmacologically high concentrations. [1.7] [#Alzheimer’s disease] - Increased proportions of #Odoribacter and #Barnesiella and decreased proportions of Eubacterium , #Roseburia , #Lachnoclostridium and #Collinsella were seen in elders with other #Dementia types than AD. [1.8] [#Faecalibacterium prausnitzii] [#Aging] - older subjects with physical #Frailty and #Sarcopenia > Lower abundance of F. prausnitzii, as well as members of the #Clostridiales class including Eubacterium and #Roseburia genera. [1.9] [#Clostridium cluster IV, #Clostridium clusters XIVa] [#Butyrate] - The predominant butyrogenic bacterial species, including #Faecalibacterium prausnitzii, #Clostridium spp., Eubacterium spp., and #Roseburia spp., are from two clusters (#Clostridium clusters IV and XIVa) in the #Firmicutes phylum and the #Clostridiales order [#Non-Hodgkin lymphoma] [#CAR T-cell therapy] - In Lymphoma > #Bacteroides, #Ruminococcus, Eubacterium and #Akkermansia were most important in determining CAR-T responsiveness, with #Akkermansia also being associated with pre-infusion peripheral T cell levels in these patients. [1.11] [#Clostridium clusters XIVa] - Components with the[N(CH3)3] structure, such as #Choline, #Phosphatidylcholine, and L-#Carnitine, can be used by #Clostridium (primarily #Clostridium XIVa and Eubacterium) and Proteobacterium produced trimethylamine (#TMA) lyases to form #TMA. - #TMA is a foul-smelling gas that smells like rotten fish [1.12] [#Clostridium sensu stricto] - #Cranberry Extract > #Clostridium, #Clostridium sensu stricto 1 were also increased, as well another known #Butyrate-producer, #Anaerobutyricum (former Eubacterium) and #Shuttleworthia - fecal and plasmatic ratio of #Butyrate tended to increase in response to the #Cranberry extract, - the increase in the #Butyrate ratio was concomitant to a decrease of the #Acetate ratio, despite the bloom of several #Acetate-producing bacteria such as #Terrisporobacter (former #Clostridium), #Intestinibacter (former #Clostridium), #Dorea (former Eubacterium) and #Bifidobacterium [1.13] - Members of the Eubacterium family are pivotal due to their capability to produce short-chain fatty acids, notably #Butyric acidReferences Notes (1) [1.57]
