Eggerthella ⇒ Eggerthella lenta {10000209} Record Keys Parent:Eggerthella Definition:Eggerthella lenta Details Initialisation date:2019-06-16 LinksSource Meta Information Rank: Species Domain: Bacteria Enzyme:[ ] Function:Dopamin-Degrading Notes: Produces meta-tyramine from DopaminShared Reference Notes [1.1] - #Proanthocyanidins are biotransformed by #Adlercreutzia equolifaciens JCM 14793T, #Eubacterium sp. SDG-2, Eggerthella lenta rK3 and Eggerthella lenta CAT-1 and from the phylum actinomycetes, which belong to the phylum #Actinobacteria, through the cleavage of the C-ring and dihydroxylation reactions to produce (−)EGC, (−)-gallocatechin (GC), (±)EC and (±)-catechin (C) [1.2] [#Diabetes Type 2] [#Imidazole propionate] - Imidazole propionates (ImP), produced by several bacterial strains, including #Streptococcus mutans and Eggerthella lenta, which was found to be elevated in individuals with T2DM and impairs insulin signaling through activation of the p38γ-p62-mTORC1 pathway [1.3] - Eggerthella lenta JCM 9979 was shown to facilitate the C-ring cleavage of #Epicatechins and #Catechins and the subsequent 4’-dehydroxylation to produce different intermediate metabolites. [1.4] [#Allergy] [#Anaerostipes hadrus, #Blautia wexlerae, #Clostridium innocuum, #Enterococcus faecalis, #Escherichia coli, #Eubacterium hallii, #Fusicatenibacter saccharivorans, #Tyzzerella nexilis] - depletions in the bacterial species A. hadrus, F. saccharivorans, E. hallii, and B. wexlerae in participants who later developed allergic diseases, as well as enrichments in E. lenta, C. innocuum, E. faecalis, E. coli, and T. nexilis in these participants. [1.5] [#Juvenile idiopathic arthritis] [#Human breast milk] - taxa associated with ABIS JIA had a significant association with shorter durations of breastfeeding, including #Acidaminococcales, #Prevotella 9, #Parabacteroides distasonis, and several ASVs belonging to #Bacteroides, #Veillonella parvula, #Turicibacter sanguinis, Eggerthella lenta, and P. distasonis. [1.6] [#Autoimmune disease] - Naïve mice gavaged with E. lenta showed significant abundance of #Candidatus arthromitus, a segmented filamentous bacteria known to induce a potent TH17 response, and cause autoimmunity - Increasing abundance of E. lenta via gavage led to alterations in metabolic profile with reduced #Butyrate production. - Reduction in #Butyrate producing taxa, #Burtyrivibrio, after E. lenta treatment could be one of the reasons for reduced gut #Butyrate levels. [#Bile Acids, #Deoxycholic acid, #Lithocholic acid] - E. lenta gavage also altered BA metabolism as observed by increased primary and secondary BA including DCA and lithocholate (LCA) [#Rheumatoid Arthritis] - increased abundance of E. lenta in patients with seropositive RA high RF levels [#Rheumatoid Arthritis] - dysbiosis can be responsible for autoantibodies to self-proteins that share sequence similarities with bacterial products. E. lenta shares homology with certain CII peptides, and naïve mice gavaged with E. lenta generate response to those peptides. - E. lenta could result in an autoreactive response to CII-derived proteins during normal physiological processes. [#Rheumatoid Arthritis] [#Tryptophan] - Increased proportion of E. lenta led to a decrease in metabolites, N-acetylglutamine, deoxycarnitine, gamma glutamylmethionine, Trp, N-acetyltryptophan, and #Methionine, which supports our recent data in patients with RA where an increase in these metabolites was associated with a decrease in disease severity [1.7] [#Diabetes Type 1] [#Bile Acids] - Eggerthella lenta was associated with the stool concentrations of TLCA and GLCA in the P2Ab study group. - Eggerthella lenta hydroxysteroid dehydrogenases is capable of using both tauro- and glyco-conjugated BAs as substrates. - Eggerthella lenta has previously been associated with human disease and found to activate T-helper type 17 (Th17) immune cells. - Eggerthella lenta as an immunomodulatory microbe. [1.8] [#β-blocker] - depletion of enzymes involved in energy metabolism encoded by Eggerthella lenta due to β-blocker use.References Notes (1) [1.20]
