Caffeic acid {90000226}

Shared Reference Notes

• [1.1] [#Depression] 
  - #Combination of probiotics and polyphenol-rich prebiotics, a synbiotic >attenuates the chronic-stress induced inflammatory responses in the ileum and the prefrontal cortex promoting > resilience to the consequent depressive- and #Anxiety-like behaviors in male mice. - This effect may be attributed to specific synbiotic-produced metabolites including #4-hydroxyphenylpropionic, #4-hydroxyphenylacetic acid and caffeic acid > promoted anti-inflammatory activity through the aryl hydrocarbon receptor (AHR).
• [1.2] [#Polyphenol-rich supplementation] 
  - Four dietary #Polyphenols (rutin, #Quercetin, chlorogenic acid, and caffeic acid) can reduce the ratio of #Firmicutes to #Bacteroides in in vitro gut microbiota experiments.
• [1.3] [#Bifidobacterium animalis] 
  - B. animalis > ester hydrolysis of #Chlorogenic acid to release caffeic acid.
• [#Caffeic acid phenethyl ester] - The derivative of caffeic acid, caffeic acid phenethyl ester, also has a battery of neuroprotective activities including anti-inflammatory and immunomodulatory properties whose production is dependent on the gut microbiota
• [#Depression] - In mice, caffeic acid (4 mg/kg) was shown to have antidepressant-like activity independent of monoamine transduction suggesting that caffeic acid works through a non-monoameringeric system
• [#Lipopolysaccharide] - Caffeic acid, at a dose of 30 mg/kg body weight in mice, prophylactically inhibited LPS-induced sickness behavior specifically by reducing cytokine production in serum and brain thus eliciting a protective effect against neuropathologies associated with #Depression
• [#Lactobacillus plantarum, #Streptococcus thermophilus] [#Cypto-chlorogenic acid] - mulberry #Anthocyanins were specifically transformed by S. thermophilus (46.2%) and L. plantarum (43.6%) into #Chlorogenic acid, cypto-#Chlorogenic acid, caffeic acid and #Ferulic acid: all #Phenolic acids with potent anti-inflammatory benefits.
• [1.4] [#Phenolic acids] [#Oat] 
  - Phenolic compounds found in oats include caffeic acid, #Coumaric acid, #Phytic acid, #Gallic acid, and #Vanillic acid

References Notes