Disease ⇒ Endometriosis {40000403}

Shared Reference Notes

• [1.1] 
  - enhanced IL-1β signaling, which occurs in response to inflammasome activation, promotes endometriotic angiogenesis. - peritoneal fluid of women with endometriosis has elevated IL-1β, which promotes the release of cytokines, such as Interleukin 8 (IL-8), and growth factors that contribute to neovascularization and monocyte chemotaxis in endometriotic explants.
• - Increased abundance of #Acidovorax, #Devosia, #Methylobacterium, #Phascolarctobacterium, and #Streptococcus in the peritoneal fluid of endometriosis patients
• [#Antibiotic Therapy] - treatment with either broad-spectrum antibiotics or metronidazole after lesion initiation reduced lesion growth in a surgical model of endometriosis
• - n-#Butyrate protects against endometriosis disease progression in mouse model of this disease
• - women with endometriosis had elevated #Gardnerella, #Streptococcus, #Escherichia, #Shigella, and #Ureoplasma in their cervix and elevated #Shigella/#Escherichia in their stool
• - microbiota-depleted (MD) mice showed reduced endometriotic lesion growth and, the transplantation of gut microbiota by oral gavage of feces from mice with endometriosis rescued the endometriotic lesion growth. - #Quinic acid promoted the survival of endometriotic epithelial cells in vitro and lesion growth in vivo but not the establishment of lesions.

References Notes