Disease ⇒ Behcet’s Disease {40000121}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Behcet’s Disease

Details
Initialisation date:	2020-09-06
Other Terms:	BD, Behçet Disease

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10004213
MedDra Level:	pt
ICD:	[ ]
Category:	Rheumatology, Immunology
Zone:	[ ]
Mechanism:	Gut Inflammation, Leaky gut, Reduced SCFA

Notes:

- A significant decrease of butyrate production in patients was demonstrated (1)
- Lack of butyrate (antiinflamatory) > Lack of Mucin

Shared Reference Notes

[1.1] [#Butyrate]
[1.2] [#Butyrate, #Lactate, #Lipopolysaccharide]
- These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
- a similar effect was observed by the administration of #Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of #Colchicine, which is used to treat BD patients.
[1.3]
- Depleted #Dorea, #Blautia, #Coprococcus, #Erysipelotrichaceae and #Lachnospiraceae as well as enriched #Bilophila and #Stenotrophomonas were identified in BU patients.
- A peptide antigen (SteTDR) encoded by BU specifically enriched #Stenotrophomonas was identified to share homology with IRBP161-180. - Addition of the SteTDR peptide to the classical IRBP immunization protocol exacerbated EAU severity.
[1.4]
- Behcet’s disease > Stool samples were enriched with #Parabacteroides, sulphate-reducing bacteria #Bilophila and #Desulfovibrionaceae species. In addition, it was also noted that #Butyrate-producing bacteria #Clostridium and methanogens were reduced. - Transplantation of BD faeces in mice illustrated remarkable results in which gut integrity was breached due to decreased expression of tight junctions, with the subsequent effects of experimental uveitis.
[1.5]
- decrease in the proportion of #Butyrivibrio species in the intestinal tracts of patients with Behcet’s disease.

References Notes

[ ]

↥ Microbiota

‐ Acidaminococcus Stool Human [1.6]
‐ Bacteroides eggerthii Stool Human [1.7]
‐ Bifidobacterium bifidum Stool Human [1.6]
‐ Bifidobacterium dentium Saliva Human [1.8]
‐ Bifidobacterium Stool Human [1.9]
‐ Bilophila Stool Human [1.2, 1.7]
‐ Collinsella aerofaciens Stool Human [1.7]
‐ Eggerthella lenta Stool Human [1.6]
‐ Eggerthella Stool Human [1.9]
‐ Eubacterium rectale Ameliorative Gut Lumen Human [1.2]
‐ Fusobacterium Stool Human [1.7]
‐ Haemophilus parainfluenzae Saliva Human [1.10]
‐ Lactobacillus iners Stool Human [1.6]
‐ Lactobacillus mucosae Stool Human [1.6]
‐ Lactobacillus salivarius Stool Human [1.6]
‐ Mitsuokella multacida Stool Human [1.7]
‐ Oscillibacter Stool Human [1.7]
‐ Parabacteroides Stool Human [1.7]
‐ Paraprevotella clara Stool Human [1.7]
‐ Paraprevotella Stool Human [1.2, 1.7]
‐ Prevotella histicola Saliva Human [1.8]
‐ Rothia Tissue biopsie Human [1.8]
‐ Streptococcus Stool Human [1.6]

↧ Microbiota

‐ Acidiphilium Stool Human [1.7]
‐ Actinomyces graevenitzii Saliva Human [1.10]
‐ Alistipes Stool Human [1.7]
‐ Alloprevotella Saliva Human [1.10]
‐ Anaerotruncus Stool Human [1.7]
‐ Atopobium parvulum Saliva Human [1.10]
‐ Bacteroidetes Saliva Human [1.10]
‐ Bulleidia moorei Saliva Human [1.10]
‐ Butyrivibrio Stool Human [1.6]
‐ Campylobacter concisus Saliva Human [1.8]
‐ Campylobacter Saliva Human [1.10]
‐ Clostridiales Saliva Human [1.10]
‐ Clostridium Stool Human [1.7]
‐ Coprococcus Stool Human [1.7]
‐ Dialister invisus Stool Human [1.7]
‐ Eubacterium Stool Human [1.7]
‐ Filifactor Stool Human [1.6]
‐ Fusobacterium mortiferum Stool Human [1.7]
‐ Fusobacterium periodonticum Saliva Human [1.8]
‐ Gemella sanguinis Saliva Human [1.8]
‐ Lachnoanaerobaculum orale Saliva Human [1.10]
‐ Lachnospiraceae Saliva Human [1.10]
‐ Leptotrichia Saliva Human [1.10]
‐ Megamonas hypermegale Stool Human [1.6]
‐ Megamonas Stool Human [1.9]
‐ Megasphaera elsdenii Stool Human [1.7]
‐ Methanoculleus Stool Human [1.7]
‐ Methanomethylophilus Stool Human [1.7]
‐ Neisseria Saliva Human [1.8]
‐ Neisseria Tissue biopsie Human [1.8]
‐ Oribacterium sinus Saliva Human [1.8]
‐ Prevotella copri Causal? Gut Lumen Human
‐ Prevotella enoeca Saliva Human [1.10]
‐ Prevotella pallens Saliva Human [1.10]
‐ Prevotella Stool Human [1.9]
‐ Pyramidobacter piscolens Stool Human [1.7]
‐ Roseburia Causal? Gut Lumen Human
‐ Roseburia Stool Human [1.11]
‐ Selenomonas Saliva Human [1.10]
‐ Streptococcus infantis Stool Human [1.6]
‐ Subdoligranulum Causal? Gut Lumen Human
‐ Subdoligranulum Stool Human [1.11]
‐ TM7 Saliva Human [1.10]
‐ Veillonella Saliva Human [1.10]
‐ Veillonella Tissue biopsie Human [1.8]

Impact by Microbiota

[ ]

↥ Metabolome

‐ Butyrate Ameliorative [1.1, 1.2]
‐ Lactate Stool Human [1.2]

↧ Metabolome

‐ Butyric acid Causal? Stool Human [1.2]
‐ Sulfate Stool Human [1.2]

Impact by Metabolome

[ ]

Related Factor

[ ]

Subclass

[ ]

References

(1) [Link REMOVED] [2015] Behçet’s syndrome patients exhibit specific microbiome signature.

MetaBiom
Identifier: 40000121
URL: https://www.metabiom.org/disease/20/behcets-disease
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome [2021] [Research] [Circulation Research] [Journal] [80002329]
[1.2] Findings on the Relationship Between Intestinal Microbiome and Vasculitis [2022] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002464]
[1.3] Gut microbial signatures and their functions in Behcet’s uveitis and Vogt-Koyanagi-Harada disease [2023] [Journal of Autoimmunity] [Journal] [80002936]
[1.4] The Link Between Gastrointestinal Microbiome and Ocular Disorders [2023] [80003145]
[1.5] Cross-talk between the gut microbiota and hypothyroidism: a bidirectional two-sample Mendelian randomization study [2024] [Frontiers in nutrition] [Journal] [80003712]
[1.6] Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients witch Behcet’s disease [2019] [Clinical Rheumatology] [Journal] [80001223]
[1.7] A metagenomic study of the gut microbiome in Behcet’s disease [2018] [Microbiome] [Journal] [80000793]
[1.8] The oral mucosal and salivary microbial community of Behcet’s syndrome and recurrent aphthous stomatitis [2015] [Journal of Oral Microbiology] [Journal] [80000423]
[1.9] Bifidobacteria abundance-featured gut microbiota compositional change in patients with Behcet’s Disease [2016] [PLOS ONE] [Journal] [80000346]
[1.10] Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet’s disease [2016] [Clinical Immunology] [Journal] [80000770]
[1.11] Behçet’s syndrome patients exhibit specific microbiome signature [2015] [Autoimmunity Reviews] [Journal] [80000507]

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Disease ⇒ Behcet’s Disease {40000121}

Record Keys

Details

Links

Meta Information

Notes:

Shared Reference Notes

References Notes

Common References