Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Disease ⇒ Obstructive sleep apnea-hypopnea syndrome {40000400}

Record Keys

Parent:[  ]
Obstructive sleep apnea-hypopnea syndrome


Initialisation date:[  ]
Other Terms:

Meta Information

MedDra ID:
MedDra Level:
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]


[  ]

Shared Reference Notes

  • [1.1] [#Fecal Microbiota Transplantation
    - IH-FMT mice exhibited increased aBP and TMAO levels, and impairments in aortic and coronary artery function that were abrogated by #Probiotic administration.
  • [1.2
    - Intermittent hypoxia associated with obstructive #Sleep apnea (OSA) is associated with Gut Microbiota composition and diversity changes.
  • [1.3] [#Hypertension
    - the OSA-related hypoxia parameters were associated with the relative abundance of 128 gut bacterial species, including higher abundance of #Blautia obeum and #Collinsella aerofaciens. - #Collinsella aerofaciens was also independently associated with increased systolic BP.
  • - OSA-related hypoxia, but not the number of apneas/hypopneas, is associated with specific gut microbiota species and functions. - the cumulative time in hypoxia during sleep was associated with the abundance of genes involved in nine gut microbiota metabolic pathways, including #Propionate production from #Lactate.
  • [1.4
    - OSAS patients presented higher #Melatonin levels in the afternoon than control subjects who did not snore. - The #Melatonin secretion pattern in OSAS patients shows values in a plateau without the nocturnal peak found in healthy control subjects.

References Notes

[  ]