Short Chain Fatty Acid ⇒ Butanoic acid {90000663} Record Keys Parent:Short Chain Fatty Acid Definition:Butanoic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - butanoic acid was detected by WGCNA and ML as a biomarker associated with ASD. > as a biomarker associated with ASD patients specifically over 5 years of age > hypothesis of pathogenetic effects triggered by butanoic acid in #Autism [#Autism] [#Propanoic acid] - GM core volatilome for all ASD patients was characterized by over-production of 1-pentanol, 1-butanol, phenyl ethyl alcohol; benzeneacetaldehyde, octadecanal, tetradecanal; #Methyl isobutyl ketone, 2-hexanone, acetone; acetic, propanoic, 3-methyl-butanoic and 2-methyl-propanoic acids; #Indole and #Skatole; and o-cymene. [#Autism] [#Propanoic acid, #Short Chain Fatty Acid] - a bi-directional perturbation of the dopaminergic pathways by both propanoic and butanoic acids has been described, suggesting that a similar dysregulation of brain catecholaminergic system occurs, as a response, in the presence of excessive concentrations of SCFA - butanoic acid operates as a powerful inhibitor of histone deacetylase in the regulations of the #Neurotransmitters #Norepinephrine, #Dopamine, and epinephrine, and also modulates the inflammatory and oxidative conditions of intestinal mucosa. [#Short Chain Fatty Acid] - SCFAs, particularly butanoic and #Acetic acid, can be produced by #Faecalibacterium, #Roseburia, #Sutterella, and #Prevotella References Notes[ ]
