Ruminococcaceae ⇒ Subdoligranulum {10000138}

Shared Reference Notes

• [1.1] [#Psychogenic erectile dysfunction] 
  - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and Subdoligranulum - Erectile dysfunction > decreased #Prevotella sp.9, #Blautia, #Lachnospiraceae NK4A136 groups and #Roseburia.
• [1.2] [#Rheumatoid Arthritis] 
  -IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the #Lachnospiraceae and #Ruminococcaceae families. - Analysis identified a bacterial strain from the Subdoligranulum genus that was associated with autoantibody development. - Mice colonized with this Subdoligranulum isolate developed arthritis with pathology similar to human RA.
• [1.3] [#Diabetes Type 2] 
  - The reduction of Subdoligranulum can also be assumed to have a negative impact and is thus characteristic of type 2 diabetes mellitus disease.
• [1.4] 
  - Subdoligranulum and #Coprococcus were consistently found to be depleted in individuals with generalized #Anxiety disorder and #Depression
• - Both Subdoligranulum and #Coprococcus are involved in the production of #Butyrate
• [#Depression] [#Christensenellaceae, #Coprococcus eutactus, #Lachnospiraceae] - RuminococcaceaeUCG005 as the most important genus in predicting depressive symptoms. - #Sellimonas, #Eggerthella, #Lachnoclostridium and #Hungatella were more abundant in individuals with higher depressive symptoms. - 12 genera and 1 microbial family associated with depressive symptoms > genera #Sellimonas, #Eggerthella, #Ruminococcaceae (UCG002, UCG003, UCG005), #Lachnoclostridium, #Hungatella, Coprococcus, LachnospiraceaeUCG001, Ruminococcusgauvreauiigroup, #Eubacterium ventriosum, Subdoligranulum and family #Ruminococcaceae.
• [#Omega 3 Supplementation] - Subdoligranulum was found to be increased in #Omega 3 rich diet.
• [1.5] [#Mild Cognitive Impairment] 
  - the abundance of #Butyrate producing bacteria such as #Lachnospiraceae family, Subdoligranulum sp., #Roseburia intestinalis, and #Roseburia hominis were reduced in the gut of MCI participants compared to cognitively healthy controls.
• [1.6] [#Prostate cancer] [#Short Chain Fatty Acid] 
  - Subdoligranulum, #Lachnobacterium, #Christensenellaceae, #Lachnospira, #Rikenellaceae, #Eggerthella, and #Alistipes are members of the SCFA-producing order #Clostridiales and were shown to be more prevalent in individuals with high-grade PCA.
• [1.7] 
  - Increased numbers of #Bifidobacteria appeared to be linked to a higher risk of #Celiac Disease, while #Lentisphaerae, #Coprobacter and Subdoligranulum showed a potential association with a lower #Celiac Disease risk.
• [1.8] [#Omega 3] 
  - omega-3 rich diet has been shown to result in a significant increase in Subdoligranulum, along with other #Butyrate producers like #Anaerostipes, #Coprococcus, and #Roseburia.
• [#Depression] - Subdoligranulum, a known #Butyrate producer, has also been negatively associated with depressive symptoms in several studies.
• [#Juvenile idiopathic arthritis] - ABIS JIA had higher abundance of #Acidaminococcales, #Prevotella 9, and #Veillonella parvula and lower abundance of #Coprococcus, Subdoligranulum, #Phascolarctobacterium, #Dialister spp., #Bifidobacterium breve, #Fusicatenibacter saccharivorans, #Roseburia intestinalis, and #Akkermansia muciniphila
• - A particular strain of Subdoligranulum from an individual at risk for #Rheumatoid Arthritis (RA) was recently demonstrated to colonize germ-free mice and generate joint swelling similar to early RA by stimulating complement activation and IgG autoantibodies
• [1.9] [#Bacteroides-Prevotella group, #Ruminococcus gauvreauii] 
  - marked reduction in #Butyrate-producing bacterial genera, such as #Coprococcus, and Subdoligranulum, in both the ileum and colon; #Faecalibacterium in colon; and [#Ruminococcus] gauvreauii group in fecal samples from People living with HIV (PLWH)
• - #Erysipelotrichaceae UCG-003, #Coprococcus, #Faecalibacterium, and Subdoligranulum, significantly lower in PLWH and were associated with slower rates of biological #Aging.
• [#CVD] [#Bacteroides-Prevotella group] - CAD > increased #Prevotella genus, #Catenibacterium genus, #Pseudomonas genus, and Subdoligranulum.

References Notes