IL-17 {90000557}

Shared Reference Notes

• [1.1] [#TNF-alfa] 
  - anti-inflammatory cytokines (IL-4 and #IL-10) and proinflammatory cytokines (TNF-a, #IL-1b, #IL-2, #IL-6, #IL-8, #IL-12, IL-17, and #IL-18) are significantly changed by #Lactobacillus rhamnosus GG (LGG)
• [1.2] [#IL-1b, #TNF-alfa] 
  - Periodontal pathogens affect growth of local concentrations of various cytokines including interleukin-1β (IL-1β), #IL-6, IL-17, #IL-23, tumor necrosis factor-α (TNF-α), and matrix metalloproteinases MMP-8 and MMP-9
• [1.3] [#Inflamatory bowel disease] 
  - Increased Th17 immune responses are associated with many autoimmune diseases, including IBD. - Th17 cells activation could aggravate intestinal inflammation through expressing IL-17 together with other pro-inflammatory cytokines.
• [1.4] [#Rheumatoid Arthritis] 
  - #Prevotella, #Ruminococcaceae and #Clostridia were associated with RA because they induce the inflammatory response mediated by #IL-6, IL-17 and IFN-γ cytokines
• [1.5] 
  - IL-17 has been shown to play a role in the progression of #Colorectal cancer through various signaling pathways, including signal transducer and activator of transcription 3 (STAT3), nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK) pathways.
• [#Inflamatory bowel disease] - IL-17 is a cytokine that is thought to contribute to the development of IBD, which expressed at higher levels in IBD patients compared to healthy controls. - the non-inflamed mucosa of IBD patients exhibits significantly lower IL-17 levels compared to inflamed mucosa.
• [#Ruminococcus gnavus] - R. gnavus can induce the secretion of IL-17
• [1.6] [#Systemic lupus erythematosus] [#Lactobacillus delbrueckii] 
  - Compound probiotics (#Lactobacillus rhamnosus and Lactobacillus del brueckii) prophylactically fed SLE model mice for 2 months, the levels of related autoantibodies and the frequency of Th1 and Th17 cells in the spleen were decreased; meanwhile, the serum pro-inflammatory factors IL-17 and IFN-γ levels decreased
• [1.7] 
  - #Resveratrol and #Resveratrol-related PCs (e.g. pterostilbene) have further demonstrated to alleviate intestinal inflammation in mice with #Colitis by regulating the Th17/Treg balance and control the levels of plasmatic and intestinal mucosal cytokines such as transforming growth factor beta (TGF-β), #IL-6, #IL-10 and IL-17, restoring the percentage of CD4+ T cells in mesenteric lymph nodes (MLNs) and decrease their number in the intestinal LP, as well as reducing the percentage of macrophages in both regions
• [#Parkinson’s Disease] - #Chicory acid in mice with MPTP-induced PD and verified that this PC prevented dopaminergic brain lesions and glial activation, simultaneously reverting the disease-induced alterations in IL-17, IFN-γ and TGF-β levels in both the spleen and colon
• [1.8] 
  - Intestinal nematode infections trigger the activation of the host immune system, including the IL-17 and #IL-23 pathways. - IL-17 may promote inflammatory responses leading to tissue damage, but may also play a role in parasite clearance.

References Notes