Calprotectin {60000069}

Shared Reference Notes

• [1.1] [#Inflamatory bowel disease] 
  - Gut metagenomic profiles of patients with inflammatory bowel disease (IBD) are highly correlated with fecal calprotectin levels, a biomarker for severity of inflammation in IBD.
• [1.2] [#Parkinson’s Disease] 
  - detection of calprotectin, a faecal marker of inflammation by ELISA, may be helpful in detecting early signs of the activated colonic immune system in PD
• [1.3] [#Parkinson’s Disease] 
  - Other possible inflammatory markers of PD are calprotectin and #Zonulin. - The first is a marker of inflammation, while the second is a junction protein, which, if modulated by proinflammatory signals (e.g., LPS), can lead to an increase in intestinal membrane permeability. - both fecal and serum levels of calprotectin and #Zonulin are elevated in patients with PD
• [1.4] [#Multiple Sclerosis] 
  - fecal #Lipocalin-2 (Lcn-2), a biomarker of intestinal inflammation, was significantly elevated and predominantly produced by the gut-infiltrating neutrophils. - The elevation of fecal Lcn-2 levels correlated with reduced bacterial diversity and increased levels of other intestinal inflammation markers including neutrophil elastase and calprotectin.
• [1.5] 
  - cCLP as a key molecule of inflammation, which is not synthesized in the liver but produced by activated neutrophils in damaged tissues.
• - High cCLP serum levels are associated with worse structural outcomes in #Rheumatoid Arthritis and to a lesser extent, in #Spondyloarthritis.
• [1.6] [#Systemic lupus erythematosus] 
  - In SLE patients, increased fecal albumin and calprotectin were found in the stool sample
• [1.7] 
  - faecal calprotectin reaches the gut via migration of neutrophils into gastrointestinal tissues due to inflammatory processes
• [#Clostridium difficile associated disease, #Clostridium difficile infection] - Elevated calprotectin levels correlated significantly with R-CDI
• [#Clostridium difficile associated disease, #Clostridium difficile infection] - patients who are likely to develop R-CDI have higher levels of calprotectin, together with a higher abundance of #Fusobacterium and lower abundance of #Senegalimassilia, #Prevotella and #Ruminococcus.
• [1.8] [#Inflamatory bowel disease] 
  - IBD is associated with several biochemical and hematological changes, which are often used to support the diagnostic process, including vitamin and mineral deficiencies,13,14 anemia,15 increases in inflammatory markers, including #C-reactive protein (CRP) and fecal calprotectin (f-cal), and/or clinically measurable manifestations of associated liver disease. - the median values for all blood test results (indeed, all test results apart from fecal calprotectin) were within their respective normal ranges
• [1.9] [#Metabolic associated fatty liver disease] 
  - higher plasma calprotectin levels are associated with suspected MAFLD and the risk of all-cause mortality. - elevated fecal calprotectin (FC) levels in a pediatric cohort, including patients with #Obesity and MAFLD.
• [#Colorectal cancer] - #Fusobacterium nucleatum, did not significantly associate with CRC diagnostic groups (healthy, adenoma and carcinoma) when controlling for covariates transit time, fecal calprotectin (intestinal inflammation) and body mass index as primary microbial covariates. - In contrast, the associations of #Anaerococcus vaginalis, #Dialister pneumosintes, #Parvimonas micra, #Peptostreptococcus anaerobius, #Porphyromonas asaccharolytica and #Prevotella intermedia remained robust, highlighting their future target potential.

References Notes