Stearic acid {60000089} Record Keys Parent:[ ] Definition:Stearic acid Queue:[ ] Details Initialisation date:2020-10-04 Specification: 9,10-dichloro-octadecanoic acidSource: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Oleic acid] - administration of oleic and stearic acids exacerbated #Psoriasis-like symptoms: [#Oleic acid] - mice with severe #Psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms > increased the abundance of #Prevotella, while decreasing that of #Parabacteroides distasonis, in the colon > increasing the abundance of oleic and stearic acids. [1.2] - stearic acid, similar to #Palmitic acid, forms crystallite surfaces that display bactericidal activity against #Pseudomonas aeruginosa and #Staphylococcus aureus. [#Infants] - Stearic acid is found in high concentrations in infant brain grey matter, suggesting important implications for neurogenesis [1.3] - stearic acid is considered relatively neutral when compared to some other saturated fatty acids. - It holds a significant role in various bodily processes such as inflammation regulation, coagulation, #Glucose balance, and bile acid metabolism. [#Irritable bowel syndrome] - significant difference in stearic acid levels between IBS patients and healthy individuals. - diet enriched with stearic acid led to reduced concentrations of fecal #Secondary bile acids (SBA). - These SBA can impact intestinal function, including factors like intestinal peristalsis and mucosal permeability, which may have a key role in the mechanism of IBSReferences Notes[ ]
