Phytoestrogen {90000355}

Shared Reference Notes

• [1.1] [#Multiple Sclerosis] [#Isoflavone diet, #Phytoestrogen-free (phyto-free) diet] 
  - gut microbiota of MS Patients resembles the gut microbiota of mice raised under a phytoestrogen-free (phyto-free) diet in that it lacks phytoestrogen-metabolizing bacteria. - the change in diet from one that is ISO to one that is PF reduces beneficial bacteria such as Bifidobacterium species. - isoflavone-rich diet specifically modulates LPS biosynthesis of the gut microbiota imparts an anti-inflammatory response and decreases disease severity
• [1.2] 
  - gut bacteria can metabolize isoflavones into #Equol, which has a higher affinity for endogenous estrogen receptors compared to dietary isoflavones. - #Isoflavone-rich diet can protect from neuroinflammatory diseases, and that protection was dependent on the ability of gut bacteria to metabolize isoflavones into #Equol. - mice on a diet with isoflavones showed an anti-inflammatory response compared to the mice on a diet lacking isoflavones.
• - patients with #Multiple Sclerosis (MS), a neuroinflammatory disease, lack gut bacteria that are able to metabolize phytoestrogen.

References Notes