Microbiome & Chronic Diseases

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Phytoestrogen {90000355}

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Shared Reference Notes

  • [1.1] [#Multiple Sclerosis] [#Isoflavone diet, #Phytoestrogen-free (phyto-free) diet
    - gut microbiota of MS Patients resembles the gut microbiota of mice raised under a phytoestrogen-free (phyto-free) diet in that it lacks phytoestrogen-metabolizing bacteria. - the change in diet from one that is ISO to one that is PF reduces beneficial bacteria such as Bifidobacterium species. - isoflavone-rich diet specifically modulates LPS biosynthesis of the gut microbiota imparts an anti-inflammatory response and decreases disease severity
  • [1.2
    - gut bacteria can metabolize isoflavones into #Equol, which has a higher affinity for endogenous estrogen receptors compared to dietary isoflavones. - #Isoflavone-rich diet can protect from neuroinflammatory diseases, and that protection was dependent on the ability of gut bacteria to metabolize isoflavones into #Equol. - mice on a diet with isoflavones showed an anti-inflammatory response compared to the mice on a diet lacking isoflavones.
  • - patients with #Multiple Sclerosis (MS), a neuroinflammatory disease, lack gut bacteria that are able to metabolize phytoestrogen.

References Notes

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