Aspirin {90000508} Record Keys Parent:[ ] Definition:Aspirin Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Colon adenomas, #Colorectal cancer] [#Plant-based diet] - #Flavonifractor plautii and #Bacteroides stercoris transmit the protective or carcinogenic effects of these factors to early carcinogenesis. - #Flavonifractor plautii and #Bacteroides stercoris, for example, were more abundant in people with tubular adenomas than in those with serrated adenomas or in controls. - Both microbes were also less abundant in people with an increased vegetable intake or those who took aspirin. [1.2] [#Akkermansia muciniphila] - greater increase in #Akkermansia’s abundance in aspirin vs placebo > aspirin users, who do not have severe upper Gl complications, are likely to have increased mucin levels that contribute to host defense and potentially to a decrease in inflammation. - The abundance of #Akkermansia increased more in the aspirin compared to the placebo group [#Clostridium cluster XVIII, #Clostridium clusters XIVa] - Aspirin > differentially abundant > #Prevotella, #Veillonella, Clostridium XIVa and Clostridium XVIII clusters [#Inflamatory bowel disease] - The #Clostridium XlVa cluster and #Ruminococcaceae are also reduced in those with inflammatory bowel disease (IBD) compared to those without disease, which agrees with their protective role in the gut inflammation and an anti-inflammatory effect of aspirin on the gut microbiome. [#Inflamatory bowel disease] [#Ruminococcus gnavus] - Ruminococcocus gnavus, was shown to be increased in IBD, which could explain an increased abundance of the Ruminococcocus genus in the aspirin vs placebo arm observed in our study.References Notes[ ]
