Sport {51111356} Record Keys Definition:Sport Queue:[ ] Details Initialisation date:[ ] Specification: [ ] Meta Information Type:Physical Host:[ ] Zone:[ ] Notes: - The ‘leaky gut’ phenomenon is quite abundant in endurance athletes > As a result of the decreased gastrointestinal blood flow, the intestinal epithelial wall becomes more permeable: leaky gut appears. Gut mucus decreases, immune responses to circulating LPS increase (more inflammation) and the mitochondrial activity of the enterocytes drops too, at the level of the mucosa.Shared Reference Notes [1.1] - #Physical activity is associated with reduced risks of #Colorectal cancer (CRC) incidence, recurrence and mortality. - exercise can modify the gut microbiota, and these changes are inverse to the changes seen with CRC. - exercise mediating changes promote the antitumorigenic characteristics of the gut microbiota. [1.2] - Excesive sport > #Methanobrevibacter smithii (methane-producing bacteria) is also abundant; it is associated with an excessive production of energy and carbohydrate metabolism . - Excesive sport > #Prevotella is increased, due to its high BCAA metabolism capacity (lysine biosynthesis), as well as the participation in the metabolism of #Alanine, aspartate, and #Glutamate, #Glutamine, beyond carbohydrate. [1.3] [#Reactive Oxygen Species, #Short Chain Fatty Acid] - the gut microbiota and its metabolites, such as short chain fatty acids and #Secondary bile acids, also contribute to host energy production, ROS modulation and inflammation in the gut by attenuating TNFα- mediated immune responses and inflammasomes such as NLRP3. [1.4] [#Veillonella atypica] [#Athletes] - increase in #Veillonella relative abundance in marathon runners postmarathon. - #Veillonella utilize #Lactate as their sole carbon source > at higher relative abundance postexercise > convert #Lactate to #Propionate. - V. atypica improves run time via its metabolic conversion of exercise-induced #Lactate into #Propionate, thereby identifying a natural, microbiome-encoded enzymatic process that enhances athletic performance. - intrarectal instillation of #Propionate in mouse is sufficient to reproduce the increased treadmill run time performance observed with V. atypica gavage.References Notes[ ]
