Disease ⇒ Preeclamsia {40000214}

Shared Reference Notes

• [1.1] [#Pregnancy] [#Short Chain Fatty Acid] 
  in PE: - #Acetic acid, #Propionic acid, #Isobutyric acid, and valeric acids levels were significantly higher in the PE group. - the systolic blood pressure, diastolic blood pressure, urea/creatinine ratio, and total BA of pregnant women significantly positively correlated with #Acetic acid, #Propionic acid, #Isobutyric acid, and #Valeric acid. - urea positively correlated with #Acetic acid and #Isobutyric acid. - white blood cell count and gestational age negatively correlated with #Acetic acid, #Propionic acid, #Isobutyric acid, and #Valeric acid. - total cholesterol negatively correlated with #Propionic acid and #Isobutyric acid. - the percentage of neutrophils and fetal birth weight negatively correlated with #Isobutyric acid and #Valeric acid. - #Acetic acid and #Propionic acid have high diagnostic value for PE.
• [1.2] 
  - PE have been observed to exhibit “#Atherosclerosis-like” lesions in the spiral arteries of their placentas, accompanied by lipid accumulation. - rats model > TMAO-induced reactive oxygen species in remodeling spiral arterial defects in the placenta, which may contribute to the onset of PE
• [#Gestational Hypertension] - the relative abundance of #Methanobrevibacter is higher in healthy controls than in HDP cases during both early and late pregnancies.
• [#Short Chain Fatty Acid] - In the late trimester, the relative abundance of #Anaerovibrio was significantly decreased in PE patients, which is a short-chain fatty acid (SCFA) #Butyrate-producing bacteria.
• - #Butyrate promotes the effect on macrophage autophagy by decreasing autophagy receptors like P62 level and elevating LC3-II/LC3-I ratio, thus alleviating PE symptoms in rats.
• - #Methanobrevibacter is negatively correlated with PE and this association is still significant after adjusting for covariates such as alcohol drinking, smoking, and T2D.
• - the methanogenesis pathway mediated by #Methanobrevibacter has been shown to reduce serum #TMAO levels, thereby reducing the risk of PE
• - Trimethylamine-N-oxide (#TMAO), a gut microbiota-derived metabolite, has been found to be significantly enriched in PE patients

References Notes