Disease ⇒ Clostridium difficile associated disease {40000281}
Type: | Disease |
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Parent: | [ ] |
Definition: | Clostridium difficile associated disease |
Initialisation date: | [ ] |
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Other Terms: | CDAD |
MedDra ID: | 10009653 |
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MedDra Level: | hlt |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- #Vancomycin is used for C. difficile (CDI) which is associated with decrease in number of gut microbes like #Bacteroidetes, #Fuminococcus, and #Faecalibacterium and increases in #Proteobacteria species. - [1.2]
-#Bile Salt hydrolases (BSH) enzymes can restrict the growth of the deadly #Colitis-inducing bacterium #Clostridioides difficile. - [#Primary bile acids, #Tauro-cholic acid] - #Bile Salt hydrolases (BSHs) comprise a diverse family of microbial enzymes that catalyse critical BA transformation. - Primary conjugated BAs synthesized in the liver, such as the tauro- and glycoconjugates of #Cholic acid (TCA, GCA), are deconjugated by BSHs to generate #Cholic acid (CA)
- [#Clostridioides difficile] [#Bile Acids] - Conjugated BAs may suppress the expression of C. difficile’s toxin A.
- [#Clostridioides difficile] [#Bile Acids] - #Taurine conjugates inhibit growth less, while #Glycine conjugates and deconjugated BAs are much more toxic to C. difficile.
- [#Clostridioides difficile] [#Tauro-cholic acid] - TCA acts as a germinant for C. difficile spores, whereas #Chenodeoxycholic acid (CDCA) can inhibit germination and growth
- [1.3] [#Clostridioides difficile]
- [1.4] [#Clostridium difficile infection] [#Clostridioides difficile]
- [1.5] [#Clostridium difficile infection]
- Elevated #Calprotectin levels correlated significantly with R-CDI - [#Clostridium difficile infection] - patients who are likely to develop R-CDI have higher levels of #Calprotectin, together with a higher abundance of #Fusobacterium and lower abundance of #Senegalimassilia, #Prevotella and #Ruminococcus.
- - #Fusobacterium increased in abundance, while #Collinsella, #Senegalimassilia, #Prevotella and #Ruminococcus decreased in patients with recurrent versus non-recurrent disease.
References Notes
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