Disease ⇒ Clostridium difficile associated disease {40000281} Record Keys Type:Disease Parent:[ ] Definition:Clostridium difficile associated disease Details Initialisation date:[ ] Other Terms:CDAD Meta Information MedDra ID:10009653 MedDra Level:hlt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - #Vancomycin is used for C. difficile (CDI) which is associated with decrease in number of gut microbes like #Bacteroidetes, #Fuminococcus, and #Faecalibacterium and increases in #Proteobacteria species. [1.2] -#Bile Salt hydrolases (BSH) enzymes can restrict the growth of the deadly #Colitis-inducing bacterium #Clostridioides difficile. [#Primary bile acids, #Tauro-cholic acid] - #Bile Salt hydrolases (BSHs) comprise a diverse family of microbial enzymes that catalyse critical BA transformation. - Primary conjugated BAs synthesized in the liver, such as the tauro- and glycoconjugates of #Cholic acid (TCA, GCA), are deconjugated by BSHs to generate #Cholic acid (CA) [#Clostridioides difficile] [#Bile Acids] - Conjugated BAs may suppress the expression of C. difficile’s toxin A. [#Clostridioides difficile] [#Bile Acids] - #Taurine conjugates inhibit growth less, while #Glycine conjugates and deconjugated BAs are much more toxic to C. difficile. [#Clostridioides difficile] [#Tauro-cholic acid] - TCA acts as a germinant for C. difficile spores, whereas #Chenodeoxycholic acid (CDCA) can inhibit germination and growth [1.3] [#Clostridioides difficile] [1.4] [#Clostridium difficile infection] - Elevated #Calprotectin levels correlated significantly with R-CDI [#Clostridium difficile infection] - patients who are likely to develop R-CDI have higher levels of #Calprotectin, together with a higher abundance of #Fusobacterium and lower abundance of #Senegalimassilia, #Prevotella and #Ruminococcus. - #Fusobacterium increased in abundance, while #Collinsella, #Senegalimassilia, #Prevotella and #Ruminococcus decreased in patients with recurrent versus non-recurrent disease.References Notes[ ]
