Disease ⇒ Periodontal disease {40000225}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Periodontal disease

Details
Initialisation date:	[ ]
Other Terms:	[ ]

Meta Information
MedDra ID:	10034536
MedDra Level:	pt
ICD:	[ ]
Category:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

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Shared Reference Notes

[1.1]
-#Streptococcus salivarius K12 and M18 prevented immune activation induced by periodontal disease pathogens.
[1.2]
- Coexisting #Hypertension and periodontal disease > increased #Neisseria and #Solobacterium genera
[1.3]
- #Saccharibacteria species > reduce inflammation and consequential bone loss by modulating host bacterial pathogenicity in a mouse ligature-induced periodontitis model.
[1.4] [#Chronic periodontitis]
- #Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (#Leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).
[1.5] [#Secretory calcium-binding phosphoprotein proline-g]
- Secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1), a protein normally produced by the gingival epithelium to mediate its attachment to teeth, was suggested to be bactericidal. - Incubation of #Porphyromonas gingivalis, a major periodontopathogen, with the full-length protein resulted in decrease in bacterial number, formation of aggregates and membrane disruptions.
[1.6] [#Multiple Sclerosis] [#Porphyromonas gingivalis] [#Lipopolysaccharide]
- in periodontitis-diseased tissues, P. gingivalis was present, but not much LPS was evident in tissues. - these bacterial lipids accumulate in structures in blood vessels that can lead to thickening or blockages called atheromas. - in the blood of MS patients, and they found that the bacterial lipid levels were lower in MS patients, a very surprising result. They expected, if anything, that patients with the autoimmune disease would have more lipid present.
[1.7]
- Transplantation of periopathogenic microbiota from the SP patients altered the caecal microbiota and induced low-grade intestinal inflammation in mice. - The abundance of #Porphyromonadaceae and #Fusobacterium, which are co-pathogens in periodontitis and intestinal inflammation was significantly enriched in the gut of the C-SP group. - Interestingly, #Porphyromonadaceae was also enriched in the salivary samples from the humans, revealing the close relationship between the salivary and gut microbiota.
[1.8]

References Notes

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↥ Microbiota

‐ Anaeroglobus geminatus Subgingival plaque Human [1.9]
‐ Anaeroglobus Oral swab Human [1.10]
‐ Anaerolineaceae Subgingival plaque Human [1.9]
‐ Catonella Subgingival plaque Human [1.11]
‐ Desulfobulbus Subgingival plaque Human [1.9]
‐ Dialister pneumosintes Subgingival plaque Human [1.9]
‐ Filifactor alocis Saliva Human [1.12]
‐ Filifactor alocis Subgingival plaque Human [1.9]
‐ Fretibacterium fastidiosum Subgingival plaque Human [1.9]
‐ Fusobacterium nucleatum Subgingival plaque Human [1.9]
‐ Johnsonella Subgingival plaque Human [1.9]
‐ Parvimonas micra Saliva Human [1.12]
‐ Parvimonas micra Subgingival plaque Human [1.9]
‐ Peptostreptococcaceae Subgingival plaque Human [1.9]
‐ Porphyromonas endodontalis Subgingival plaque Human [1.9]
‐ Porphyromonas gingivalis Saliva Human [1.12]
‐ Porphyromonas gingivalis Subgingival plaque Human [1.9]
‐ Porphyromonas Oral swab Human [1.10]
‐ Prevotella baroniae Subgingival plaque Human [1.9]
‐ Prevotella dentalis Subgingival plaque Human [1.9]
‐ Prevotella intermedia Subgingival plaque Human [1.9]
‐ Prevotella oralis Subgingival plaque Human [1.9]
‐ Prevotella Oral swab Human [1.10]
‐ Prevotella Subgingival plaque Human [1.11]
‐ Pseudoramibacter alactolyticus Subgingival plaque Human [1.9]
‐ Saccharibacteria Ameliorative Oral & Gut Lumen Mouse [1.3]
‐ Selenomonas Oral swab Human [1.10]
‐ Selenomonas Subgingival plaque Human [1.9]
‐ Streptococcus constellatus Subgingival plaque Human [1.9]
‐ Tanerella forsythia Saliva Human [1.12]
‐ Tanerella forsythia Subgingival plaque Human [1.9]
‐ Tannerella Oral swab Human [1.10]
‐ Tannerella Subgingival plaque Human [1.11]
‐ Treponema denticola Subgingival plaque Human [1.9]
‐ Treponema maltophilum Subgingival plaque Human [1.9]
‐ Treponema socranskii Subgingival plaque Human [1.9]
‐ Treponema Oral swab Human [1.10]
‐ Treponema Subgingival plaque Human [1.11]
‐ Veillonellaceae Subgingival plaque Human [1.9]

↧ Microbiota

‐ Actinomyces massiliensis Subgingival plaque Human [1.9]
‐ Actinomyces naeslundii Subgingival plaque Human [1.9]
‐ Actinomyces Oral swab Human [1.10]
‐ Actinomyces Subgingival plaque Human [1.11]
‐ Atopobium Subgingival plaque Human [1.9]
‐ Brevundimonas diminuta Subgingival plaque Human [1.9]
‐ Capnocytophaga Subgingival plaque Human [1.9]
‐ Corynebacterium Oral swab Human [1.10]
‐ Gemella haemolysans Subgingival plaque Human [1.9]
‐ Granulicatella Oral swab Human [1.10]
‐ Granulicatella Subgingival plaque Human [1.11]
‐ Haemophilus parahaemolyticus Subgingival plaque Human [1.9]
‐ Haemophilus parainfluenzae Subgingival plaque Human [1.9]
‐ Haemophilus Subgingival plaque Human [1.11]
‐ Lautropia mirabilis Subgingival plaque Human [1.9]
‐ Leptothrix Subgingival plaque Human [1.9]
‐ Leptotrichia goodfellowii Subgingival plaque Human [1.9]
‐ Mitsuokella Subgingival plaque Human [1.9]
‐ Neisseria flavescens Subgingival plaque Human [1.9]
‐ Porphyrobacter tepidarius Subgingival plaque Human [1.9]
‐ Pseudomonas fluorescens Subgingival plaque Human [1.9]
‐ Rothia aeria Subgingival plaque Human [1.9]
‐ Sphingomonas echinoides Subgingival plaque Human [1.9]
‐ Sphingomonas Subgingival plaque Human [1.9]
‐ Streptococcus oralis Subgingival plaque Human [1.9]
‐ Streptococcus Subgingival plaque Human [1.11]

Impact by Microbiota

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↥ Metabolome

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↧ Metabolome

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Impact by Metabolome

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Related Factor

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Subclass

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References

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Author: MetaBiom
Identifier: 40000225
URL: https://www.metabiom.org/disease/125/periodontal-disease
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Streptococcus salivarius inhibits immune activation by periodontal disease pathogens [2020] [Research] [BMC Oral Health] [Journal] [80001831]
[1.2] Analysis of the Salivary Microbiome in the Periodontal Disease Patients with Hypertension and Non-hypertension [2021] [Cohort study] [Current Bioinformatics] [Journal] [80002177]
[1.3] Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation [2021] [Research] [Cell Host & Microbe] [Journal] [80002182]
[1.4] Rheumatoid Arthritis-Associated Autoimmunity Due to Aggregatibacter actinomycetemcomitans and Its Resolution With Antibiotic Therapy [2018] [Case Report] [Frontiers in Immunology] [Journal] [80000228]
[1.5] Effect of human secretory calcium-binding phosphoprotein proline-glutamine rich 1 protein on Porphyromonas gingivalis and identification of its active portions [2021] [Research] [Scientific Reports] [Journal] [80002347]
[1.6] in periodontitis-diseased tissues, P. gingivalis was present, but not much LPS was evident in tissues. [2022] [Report] [80002428]
[1.7] Periodontitis may induce gut microbiota dysbiosis via salivary microbiota [2022] [Study] [International Journal of Oral Science] [Journal] [80002458]
[1.8] Leaky Gum: The Revisited Origin of Systemic Diseases [2022] [Review] [Cells] [Journal] [80002693]
[1.9] The subgingival microbiome relationship to periodontal disease in older women [2019] [Journal of Dental Research] [Journal] [80001107]
[1.10] Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis [2012] [Arthtitis & Rheumatism] [Journal] [80000389]
[1.11] Deep sequencing of the oral microbiome reveals signatures of periodontal disease [2012] [PLOS ONE] [Journal] [80001205]
[1.12] Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries [2017] [npj Biofilms and Microbiomes] [Journal] [80000615]

Disease ⇒ Periodontal disease {40000225}

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Notes:

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References Notes

Common References