Disease ⇒ Ankylosing spondylitis {40000210} Record Keys Type:Disease Parent:[ ] Definition:Ankylosing spondylitis Details Initialisation date:[ ] Other Terms:AS Meta Information MedDra ID:10002556 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Acute anterior uveitis, #Crohn’s disease, #HLA-B27-associated disease, #Psoriasis, #Psoriatic Arthritis, #Ulcerative Colitis] - HLA-B27 transgenic rats that develop a spontaneous spondyloarthropathy-like illness do not develop disease when raised in a germ-free environment, but mono-association with #Phocaeicola vulgatus is sufficient to induce disease. [1.2] - Species belonging to #Sellimonas have been reported to be increased in inflammatory diseases including ankylosing spondylitis, #Atherosclerosis and liver #Cirrhosis [1.3] [#Inflamatory bowel disease] - HLA-B27 spondyloarthropathies (SpA) > ankylosing spondylitis, #Reactive arthritis, #Psoriatic Arthritis, #Juvenile idiopathic arthritis, inflammatory bowel disease, #Acute anterior uveitis, and undifferentiated SpA > segmented filamentous bacteria (SFB) have been illustrated to be a common culprit in initiating an arthritogenic reaction. - The Th17 response, induced in the mesenteric lymph nodes by dendritic cells, in such patients specifically targets SFB, resulting in a breach in the mucosal barrier. - This is thought to result from cross-reactivity between HLA-B27 and pathogenic surface antigens. - Other enteric gram-negative pathogens, which mimic HLA-B27, associated with SpA and uveitis include #Shigella, #Chlamydia and #Yersinia [1.4] [#Spondyloarthritis] - Patients with SpA showed an enrichment of #Collinsella, and several Lachnospiraceae ASVs - HLA-B27+ individuals displayed enriched #Faecalibacterium. [1.5] [#Diabetes Type 1] - #Covid-19 patients have a significantly higher risk to develop subsequent autoimmune diseases such as #Rheumatoid Arthritis, ankylosing spondylitis, #Systemic sclerosis, type I diabetes mellitus. [1.6] [#Prevotella copri, #Prevotella melaninogenica] - patients with AS and healthy controls, multiple #Prevotella species were relatively more abundant in the patient cohort. Among these, P. copri, P. melaninogenica, and #Prevotella sp. C561. [1.7] - enrichment of #Actinobacteria in patients with ankylosing spondylitis, and depletion of #Fusobacteria and #Verrucomicrobia [1.8] [#Parabacteroides distasonis] - P. distasonis is recurrent in #Crohn’s disease and elevated in ankylosing spondylitis (AS). [1.9] [#Diabetes Type 1, #Hashimoto’s thyroiditis, #Psoriasis, #Sjögren syndrome ] Patients with psoriatic disease had a significantly higher risk of #Crohn’s disease , #Ulcerative Colitis, #Systemic lupus erythematosus, #Rheumatoid Arthritis, ankylosing spondylitis , #Alopecia areata, and type 1 diabetes. - the risk of #Graves’ disease, Hashimoto’s disease, Sjögren’s syndrome, and #Systemic sclerosis was not significantly different between the groups. [#Acute anterior uveitis, #Vogt-Koyanagi-Harada] - Six microbes (#Pediococcus, #Pseudomonas, #Rhodococcus, Photobacterium, #Gardnerella and Lawsonia) and two metabolites (pyrimidine and gallocatechin) as biomarkers could effectively distinguish patients with VKH from patients with AAU and healthy individualsReferences Notes[ ]
