Fecal Microbiota Transplantation {51111224}

Shared Reference Notes

• [1.1] [#Crohn’s disease] [#Escherichia coli] 
  - Comprehensive overview of functional dysbiosis in the gut microbiome during IBD activity showed increases in facultative anaerobes, such as E. coli which correlates with inflammation status, and decreases in obligate anaerobes, such as #Faecalibacterium prausnitzii and #Roseburia hominis -The results of the present study confirmed decreases in the abundance of Firmicutes and Bacteroidetes, increases in Enterobacteriaceae, Pasteurellaceae, and Veillonellaceae and the presence of Fusobacterium in stool samples of CD patients. - #Butyrate-producing bacteria are depleted in IBD patients, and probiotic treatment with these bacteria has therapeutic potential. - A higher proportion of #Lachnospiraceae in donor stool was associated with a higher success rate of FMT, and recipients that responded to FMT exhibited increases in #Butyrate-producing #Lachnospiraceae and Ruminococcaceae. - The reduced SCFA levels in patients with IBD result from lower abundance of SCFA-producing bacteria, especially those of the phylum Firmicutes. -- #Butyrate can act as an energy source for normal colon epithelial cells, promoting their proliferation, but can also inhibit proliferation and induce apoptosis.
• [1.2] [#Alzheimer’s disease] 
• [1.3] [#Metabolic syndrome, #Obesity] [#High-fiber diet] 
• [1.4] [#Alzheimer’s disease] 
• [1.5] 
  - In #Ulcerative Colitis (UC), patients’ mycobiota revealed that those with high levels of #Candida were more likely to benefit from FMT treatment. - Amelioration of disease was associated with a decrease in #Candida following FMT.
• [1.6] 
  - faecal microbiota transplant (FMT) from wild-type into #Huntington’s Disease mice positively modulates cognitive outcomes in Huntigton’s Disease model, particularly in females.
• [1.7] [#Clostridioides difficile] 
• [1.8] [#Obstructive sleep apnea-hypopnea syndrome] 
  - IH-FMT mice exhibited increased aBP and TMAO levels, and impairments in aortic and coronary artery function that were abrogated by #Probiotic administration.
• [1.9] 
  - recipients with higher donor strain engraftment were more likely to experience clinical success after FMT. - #Bacteroidetes and #Actinobacteria species (including Bifidobacteria) displayed higher engraftment than #Firmicutes except for six under-characterized #Firmicutes species.
• [#Diabetes Type 2] [#Short Chain Fatty Acid] [#Exercise training] - exercise-induced alterations in the gut microbiota correlated closely with improvements in glucose homeostasis and insulin sensitivity. - The microbiome of responders exhibited an enhanced capacity for biosynthesis of short-chain fatty acids and catabolism of branched-chain amino acids, whereas those of non-responders were characterized by increased production of metabolically detrimental compounds. - Fecal microbial transplantation from responders, but not non-responders, mimicked the effects of exercise on alleviation of insulin resistance in obese mice.
• [1.11] [#Parkinson’s Disease] 
  - Colonic FMT > improvement and longer maintenance of efficacy compared with nasointestinal. Two patients achieved self-satisfying outcomes that last for more than 24 months. - The score of PSQI, HAMD, HAMA, PDQ-39, NMSQ and UPDRS-III significantly decreased at 1 month after FMT. - The quality of sleep and life improved after FMT treatment. - anxiety and depression were also partially relieved.
• [1.12] [#Exercise training] 
  - #Phocaeicola barnesiae, #Eisenbergiella massiliensis, and #Anaeroplasma abactoclasticum in the gut microbiome as positive contributors to #Muscle strength. - #Ileibacterium valens and #Ethanoligenens harbinense were found to have negative effects on muscle strenght.

References Notes