Prevotella ⇒ Prevotella intermedia {10000285}

Shared Reference Notes

• [1.1] [#Atherosclerosis, #CVD] [#Campylobacter rectus, #Porphyromonas endodontalis, #Porphyromonas gingivalis, #Prevotella nigrescens] 
  - 23 oral commensal bacteria, either individually or in coexistence, within carotid endarterectomy biopsies from patients undergoing surgical procedures. Of these 23 bacteria, five were unique to coronary plaques, including P. gingivalis, P. endodontalis, P. intermedia, C. rectus, and P. nigrescens.
• [1.2] [#Colorectal cancer, #Natural oral microbiomes] [#Prevotella nigrescens] 
  - A higher abundance of P. intermedia and P. nigrescens (Pretovella species that are commonly resident in the oral cavity) was observed in the intestine of CRC patients
• [#Metabolic associated fatty liver disease] - in mice experiments, oral administration of P. intermedia induces NAFLD
• [1.3] [#Actinomyces massiliensis] 
  - #Athletes from 16 different sports > dominated by a single or a combination of five species, namely #Eubacterium rectale, Polynucleobacter necessarius, #Faecalibacterium prausnitzii, #Bacteroides vulgatus, and #Gordonibacter massiliensis. - Species such as #Bifidobacterium animalis, #Lactobacillus acidophilus, Prevotella intermedia, and F. prausnitzii were associated with #Athletes participating in high dynamic component sports.
• [1.4] 
  - Some oral #Bacteria (e.g., #Porphyromonas gingivalis, Prevotella intermedia, #Aggregatibacter actinomycetemcomitans, and #Fusobacterium nucleatum) produce volatile #Sulfur compounds (VSCs), such as #Hydrogen sulfide (H2S), methyl mercaptan (CH3SH), dimethyl #Sulfide ((CH3)2S), and dimethyl disulfide (CH3SSCH3).
• [1.5] [#Colorectal cancer] [#Bacteroides fragilis, #Fusobacterium nucleatum] 
  - F. nucleatum-positive CRC tissues featured non-random co-colonization with commensals such as B. fragilis or P. intermedia, whereas tissues lacking F. nucleatum featured different bacterial colonization patterns
• [#Colorectal cancer] [#Fusobacterium nucleatum, #Porphyromonas gingivalis] - most CRC-associated microbes, such as F. nucleatum, P. gingivalis, and Prevotella intermedia (P. intermedia) are suggested to reside intracellularly.
• [#Colorectal cancer] - CRC > a higher abundance of P. intermedia was detected in adenocarcinoma samples
• [1.6] [#Cognitive impairment] 
  - serum antibody levels specific for P. intermedia have been reported to be associated with cognitive deficits
• [#Fusobacterium nucleatum, #Porphyromonas gingivalis, #Tannerella forsythia, #Treponema denticola] - P. gingivalis, T. denticola, T. forsythia, P. intermedia, F. nucleatum and #Filifactor alocis are traditionally recognized as major pathogens responsible for #Periodontal disease
• [1.7] [#Diabetes Type 2] [#Fusobacterium nucleatum, #Porphyromonas gingivalis] 
  - mice fed a high-fat diet, combined administration of P. gingivalis, F. nucleatum, and P. intermedia induced impaired blood #Glucose metabolism and insulin resistance with concomitant changes in the gut microbial composition.
• [#Metabolic associated fatty liver disease] [#Porphyromonas gingivalis] - mice fed a high-fat diet and inoculated with P. gingivalis or P. intermedia exhibited an altered gut microbiome and blood metabolism, and a shift in hepatic transcriptional expression toward an NAFLD phenotype.
• [1.8] [#Colorectal cancer] 
  - #Fusobacterium nucleatum, did not significantly associate with CRC diagnostic groups (healthy, adenoma and carcinoma) when controlling for covariates transit time, fecal #Calprotectin (intestinal inflammation) and body mass index as primary microbial covariates. - In contrast, the associations of #Anaerococcus vaginalis, #Dialister pneumosintes, #Parvimonas micra, #Peptostreptococcus anaerobius, #Porphyromonas asaccharolytica and Prevotella intermedia remained robust, highlighting their future target potential.

References Notes