Disease ⇒ Otitis Media {40000328} Record Keys Type:Disease Parent:[ ] Definition:Otitis Media Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10033078 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Natural ear microbiota] - #Streptococcus salivarius (S. salivarius), a bacterial species which populates the mouth and gut in early neonatal developmentand which is commonly found in the respiratory tract, may have a beneficial influence on the ear microbiome. - The K12 strain of S. salivarius has specifically been recognized as a potential #Probiotic for treating otitis media, due to the ability of this strain to target and suppress pathogenic bacteria in the ear. [#Candida albicans] [#IL-1b, #TNF-alfa] - introducing C. albicans into the guts of mice, a greater degree of ear swelling occurred accompanied by higher levels of proinflammatory cytokines (IL-1β, #IL-6 and TNF-α) in the ear [#Streptococcus salivarius] - The production of bacterial peptides known as ‘#Bacteriocins’, which can interfere with growth of other bacteria, makes bacterial strains such as #Lactobacillus salivarius PS7 and S. salivarius 24SMB particularly interesting with regard to their potential for treating middle ear infections [#Urolithins] - An oral supply of #Urolithin A was shown to counteract myeloperoxidase activity and inflammation within the earReferences Notes[ ]
