Siblings {51111328} Record Keys Definition:Siblings Queue:[ ] Details Initialisation date:[ ] Specification: [ ] Meta Information Type:Environment, Genetic, Socio-economic Host: Human Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] - siblings in the home to be one of the most important determinants of the developing microbiota in both the airway and gut, with significant differences in alpha diversity, beta diversity, and relative abundances of the most abundant taxa, with the specific associations being particularly apparent during the first year of life. - The age gap to the closest older sibling was more important than the number of older siblings. The signature of having siblings in the gut microbiota at 1 year was associated with protection against #Asthma at 6 years of age, while no associations were found for #Allergy. [1.2] [#Aging] - #Infants with older siblings exhibit increased gut microbiome α-diversity, faster gut microbiome maturation and earlier colonization with #Faecalibacterium species, which are known to increase the Treg/TH17 cell ratio via inhibition of HDACs and to ameliorate gut inflammation. [#Aging] - A lack of older siblings is associated with reduced gut microbiome α-diversity and reduced relative abundance of #Faecalibacterium as well as delayed maturation of the gut microbiome by the age of 12 months. [1.3] [#Juvenile idiopathic arthritis] [#Antibiotic Therapy] - #Prevotella 9 and #Acidaminococcales were higher in ABIS JIA, #Infants with antibiotic exposures, and #Infants who had siblings.References Notes[ ]
