Acetic acid {90000378}

Shared Reference Notes

• [1.1] [#Obesity] 
  - Acetic acid, a product of #Bifidobacterium spp. known to function as an appetite suppressant, was found to be most abundant in the faeces of mice following #Ginger supplementation.
• [1.2] [#Preeclamsia (PE), #Pregnancy] [#Short Chain Fatty Acid] 
  in PE: - Acetic acid, #Propionic acid, #Isobutyric acid, and valeric acids levels were significantly higher in the PE group. - the systolic blood pressure, diastolic blood pressure, urea/creatinine ratio, and total BA of pregnant women significantly positively correlated with acetic acid, #Propionic acid, #Isobutyric acid, and #Valeric acid. - urea positively correlated with acetic acid and #Isobutyric acid. - white blood cell count and gestational age negatively correlated with acetic acid, #Propionic acid, #Isobutyric acid, and #Valeric acid. - total cholesterol negatively correlated with #Propionic acid and #Isobutyric acid. - the percentage of neutrophils and fetal birth weight negatively correlated with #Isobutyric acid and #Valeric acid. - acetic acid and #Propionic acid have high diagnostic value for PE.
• [1.3] [#Diabetes Type 2] 
  - gut microbes were strongly associated with fecal levels of acetic acid and #Butyric acid , but were not associated with blood acetic acid or #Butyric acid. - The fecal #Butyric acid levels were inversely (beneficially) associated with T2D. - higher fecal #Butyric acid levels were associated with improved insulin response. - the concentration of fecal #Butyric acid was lower in T2D participants compared to those without T2D.
• [1.4] [#Neonate] 
  - Pre- and postnatal maternal #Glyphosate exposure in mice increased level of acetic acid in the offspring’s faecal samples
• [1.5] 
  - The #Kombucha microbiota, was mainly comprised of #Lactic acid bacteria, acetic acid bacteria, and yeast,
• [#Diabetes Type 2] - #Kombucha also contains acetic acid, which has been reported to have anti-diabetic properties.
• [1.6] 
  - #Bifidobacteria can ferment fibre and produce the metabolites acetic acid, #Lactic acid, B vitamins and antibacterial molecules, making it an ideal choice for a #Probiotic
• [1.7] [#Christensenellaceae, #Prevotellaceae] [#Short Chain Fatty Acid] 
  - #Berberine > the relative abundances of #Parabacteroides, Prevotellaceae_UCG-001, and Prevotellaceae_NK3B31_group increased, the relative abundance of Christensenellaceae_R-7_group decreased, and cecal SCFA levels (acetic acid and #Propionic acid) were reduced.
• [1.8] [#Cancer] [#Butyric acid, #Isobutyric acid, #Isocaproic acid, #Isovaleric acid] 
  - aciduric #Peptostreptococcus stomatis produces acetic, butyric, isobutyric, isovaleric, and isocaproic acids. - Production of such acids may contribute to the acidic and hypoxic microenvironment of tumors, thereby increasing metastatic efficiency
• [1.9] [#Tuberculosis] [#Short Chain Fatty Acid] 
  - TB infection reduced the SCFA production in feces which included significantly low levels of #Butyric acid, #Isobutyric acid, #Valeric acid, and #2-metylbutic acid. However, the levels of #Propionic acid and acetic acid were non-significantly reduced and elevated, respectively, in the TB group compared with HC.
• - GPR43 interaction with acetic or #Propionic acid upregulates the transcription factor Forkhead box protein 3 (FOXP3) to control the anti-inflammatory effect of Treg cells
• [1.11] [#Diabetes Type 2] 
  - #Blautia produces acetic acid and significantly correlates with host physiological dysfunctions, such as #Obesity, diabetes, and various inflammatory diseases. - An increase in #Blautia abundance may inhibit insulin signaling and prevent fat accumulation in adipocytes

References Notes