Roseomonas ⇒ Roseomonas mucosa {10000111} Record Keys Parent:Roseomonas Definition:Roseomonas mucosa Details Initialisation date:2020-09-06 LinksSource Meta Information Rank: Species Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: - Most children in the study experienced substantial improvements in their skin and overall wellbeing following R. mucosa therapy. Encouragingly, the therapeutic bacteria stayed on the skin and continued to provide benefit after therapy stopped. - Seventeen of the 20 children experienced a greater than 50% improvement in eczema severity following treatment. Improvement occurred on all treated skin sites, including the inner elbows, inner knees, hands, trunk and neck. The scientists also observed increases in the skin’s barrier function—its ability to seal in moisture and keep out allergen. - A specific set of lipids produced by R. mucosa strains isolated from healthy skin can induce skin repair processes and promote turnover of skin tissue. Study participants had increased levels of these lipids on their skin after treatment with R. mucosa. (1) Shared Reference Notes [1.1] [#Primary sclerosing cholangitis] [#Streptococcus salivarius] - Even in the early stages, PSC patients’ stool and mucosa significantly enrich oral pathogenic bacteria such as #Streptococcus, #Veillonella, and #Actinomyces (#Streptococcus salivarius is an independent predictor of liver-related three-year mortality) [1.2] [#Natural Skin Microbiome] - Roseomonas mucosa secretes #Glycerophospholipids which induce host epithelial repair by enhancing the cholinergic activation via TNFR2 signalling [1.3] [#Parkinson’s Disease] [#Short Chain Fatty Acid] - #Constipation severity is significantly correlated with the decrease of #Blautia and #Faecalibacterium, short chain fatty acids (SCFAs)-producing taxa that can exert positive effects on the intestinal mucosa and which are decreased in PD. [1.4] [#Eubacterium limosum] - E. limosum can reduce #Colitis, and the metabolite #Butyrate can enhance the integrity of the mucosa and show anti-inflammatory regulation on the intestinal mucosal system through Toll-like receptor 4 (TLR4) [1.5] - The #Segmented filamentous bacteria (SFB) can improve the immune response of mucosal tissues. - SFB are bacteria that can not be cultured present at weaning in the ileum of mice. - This bacterial species induces the immune response of the gut mucosa after birth. - In the absence of SFB, mice were found to possess reduced IgA titers and decreased numbers of helper T-cells (especially Th17 cells). - they had a weak response to intestinal pathogenic bacteria such as #Salmonella and #Citrobacter rodentium [1.6] [#Covid-19] [#Short Chain Fatty Acid] [#mRNA vaccine] - different bacterial groups from #Lachnospiraceae to be associated with either high or low spike IgG levels. - bacterial members belonging to the family #Lachnospiraceae are well-known producers of SCFAs in colon mucosa-associated microbiota. - #Lachnospiracea FSC020, which shows a positive association with spike IgG levels > a potential positive association with the production of #Acetate and propionat [1.7] [#Cirrhosis] - In cirrhotic patients, the relative abundances of #Veillonella, #Megasphaera, #Dialister, #Atopobium, and #Prevotella were increased in the duodenal mucosa [1.8] [#Atopic Dermatitis] - In 15 #Children with AD, R. mucosa treatment was associated with amelioration of disease severity, improvement in epithelial barrier function, reduced #Staphylococcus aureus burden on the skin, and a reduction in topical steroid requirements without severe adverse events. - Skin improvements and colonization by R. mucosa persisted for up to 8 months after cessation of treatment. [#Atopic Dermatitis] - The production of #Sphingolipids by R. mucosa, cholinergic signaling, and #Flagellin expression may have contributed to therapeutic impact through induction of a TNFR2-mediated epithelial-to-mesenchymal transition. References Notes[ ]
