Carnitine ⇒ γ-butyrobetaine {90000216} Record Keys Parent:Carnitine Definition:γ-butyrobetaine Queue:[ ] Details Initialisation date:2021-12-30 Specification: Precursor of TMASource: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Building cholesterol plaques Notes: [ ]Shared Reference Notes [1.1] - #Meat-based diet > L-carnitine > Gut microbial transformation >intermediate γ-butyrobetaine (γBB) > trimethylamine (TMA) > TMAO - Plasma γBB levels in individuals > strongly associated with incident #CVD event risks. - #Emergencia timonensis > metabolize γBB into TMA > complete the carnitine → γBB → TMA transformation > elevate TMAO levels > enhance thrombosis [1.2] [#Atherosclerosis, #Hearth attack] [#Carnitine, #Crotonobetaine, #TMAO] [#Meat-based diet] [1.3] [#Chronic fatigue syndrome] - Decreased γ-butyrobetaine correlated with increased #Faecalibacterium. [#Chronic fatigue syndrome] [#Indole-3-lactic acid] - Indole-3-lactate and γ-butyrobetaine were also reduced in the all ME/CFS group but were not amongst the top 10 plasma biomarkers.References Notes[ ]
