Saccharomycetales ⇒ Candida {10001442}

Shared Reference Notes

• [1.1] 
  - The metabolites of Candida is related with different metabolic pathways, such as amino acid metabolism and biosynthesis, fatty acids metabolism, aromatic compounds degradation, mono and sesquiterpenoid synthesis and carotenoid cleavage
• [1.2] [#Chronic Obstructive Pulmonary Disease] 
  - The oral and pulmonary mycobiomes from controls and participants with COPD were dominated by Candida - Malassezia and Sarocladium were also frequently found in pulmonary samples.
• [1.3] 
  - There is an expansion of Candida sp. and Rhodotorula sp. in stool samples from US infants that later developed #Atopy.
• [1.4] [#Crohn’s disease] [#Candida albicans, #Candida glabrata, #Candida tropicalis] 
  - Candida. A common, although not universal, finding has been an increase, statistically significant or trending, in the relative amount of Candida in the fecal mycobiome of patients with CD from diverse geographic locations. - The named species is usually C. albicans, but C. tropicalis and C. glabrata have also been reported.
• [1.5] [#Adult age] 
  - Multiple Candida spp. were at higher relative abundance in #Children than adults, while #Malassezia and certain food-associated fungi were lower in #Children.
• [1.6] [#Fecal Microbiota Transplantation] 
  - In #Ulcerative Colitis (UC), patients’ mycobiota revealed that those with high levels of Candida were more likely to benefit from FMT treatment. - Amelioration of disease was associated with a decrease in Candida following FMT.
• [1.7] [#Gastric carcinoma] 
  - Candida and #Alternaria were enriched in GC, while Saitozyma and Thermomyces were GC-depleted
• [1.8] [#Helicobacter pylori] 
  - Streptococcus, Neisseriae, Prevotella, Rothia, Fusobacterium, Veillonella, and Haemophilus are considered the main gastric bacterial genera enriched in #H. pylori-positive individuals. - the overgrowth of Candida species in the stomach has been reported during H. pylori infection, which might result in synergistic effects on the H. pylori pathogenesis.
• [1.9] [#Colorectal cancer] 
  - in colon cancers Candida > predictive of metastatic disease and attenuated cellular adhesions. - Candida DNA is enriched in tumors and predictive of reduced survival in GI cancers
• [#Stomach cancer] - In stomach cancers, high rates of Candida were linked to the expression of pro-inflammatory immune pathways
• [#Amyotrophic lateral sclerosis] - Tissue sections from different regions of the CNS of ALS patients contain fungi. - fungal structures such as yeast and hyphae in the motor cortex, the medulla and the spinal cord, in eleven patients with ALS. - Some fungal structures were localized intracellularly and even intranuclearly, indicating that this infection is not the result of post-mortem colonization. - PCR analysis and next generation sequencing of DNA extracted from frozen neural tissue identified a variety of fungal genera including Candida, #Malassezia, #Fusarium, #Botrytis, #Trichoderma and #Cryptococcus.
• [1.11] [#Oral lichen planus] 
  - Higher enrichment of the fungi Candida and #Aspergillus was identified in patients with reticular OLP than in healthy controls.

References Notes