Microbiome & Chronic Diseases

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Exercise training {50000143}

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Exercise training
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Environment, Habit, Physical
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- Exercise training enriched certain bacteria, including Parabacteroides distasonis, low levels of which lead to the development of NASH and increase cardiovascular risk. Enrichment of Parabacteroides distasonis enrichment created multiple positive co-occurring relationships with commensal gut organisms, including Lachnospiraceae and Ruminococcaceae, each of which may lessen "leaky gut," promote gastrointestinal health and interrupt disease progression in NASH.

Shared Reference Notes

  • [1.1] [#Non-alcoholic fatty liver disease
    -The exercise group showed improvements in the clinical indices of oral environment. Salivary component analysis revealed significant reductions in LPS, and lactoferrin during the exercise regimen. - Diversity analysis of oral bacterial flora revealed higher alpha- and beta-diversity after the exercise regimen. - Analysis of the microbial composition revealed that the numbers of Campylobacter, Corynebacterium, Actinomyces , and Lautropia were significantly higher, and that of Prevotella was significantly lower.
  • [1.2
    - Exercise > promote the proliferation in the populations of Veillonella strains
  • [1.3
    - Exercise increases > increase α-diversity and microbial metabolites such as SCFAs. - Exercise > typically reveal increases in commensal taxa such as #Bifidobacterium, #Lactobacilli, and #Akkermansia
  • - Single bout of exercise > upregulated metabolic pathways of skeletal muscle substrate utilization and carbohydrate metabolites in serum > increased fecal #Ammonia and amino acid metabolites > increased the abundance of #Clostridia
  • - Cardiorespiratory exercise induced immediate changes in the gut microbiota composition, while resistance exercise had no effect
  • [#High-protein diet] - protein-supplemented group without exercise > increases in trimethylamine-N-oxide (#TMAO) and #Phenylacetylglycine (PAG). - In contrast, the addition of exercise decreases #TMAO
  • [#Short Chain Fatty Acid] - SCFAs > can be oxidized > incorporated into glucose via gluconeogenesis, or increase the bioavailability of glucose, glycogen, and fatty acids during exercise. - SCFAs > increased blood flow, insulin sensitivity, skeletal muscle mass preservation, and an oxidative phenotype
  • [1.4] [#Lactobacillus plantarum
  • [1.5] [#Chronic fatigue syndrome
  • [1.6] [#Diabetes Type 2] [#Short Chain Fatty Acid] [#Fecal Microbiota Transplantation
    - exercise-induced alterations in the gut microbiota correlated closely with improvements in glucose homeostasis and insulin sensitivity. - The microbiome of responders exhibited an enhanced capacity for biosynthesis of short-chain fatty acids and catabolism of branched-chain amino acids, whereas those of non-responders were characterized by increased production of metabolically detrimental compounds. - Fecal microbial transplantation from responders, but not non-responders, mimicked the effects of exercise on alleviation of insulin resistance in obese mice.
  • [1.7
  • [1.8] [#Alzheimer’s disease
    - Exercise is protective in AD - Exercise alters Gut Microbiota composition. - The protective effect of exercise on AD progression maybe mediated by the Gut Microbiota.
  • - 5 weeks of exercise training in mice resulted in Gut Microbiota composition changes and an increase in cecal #Butyrate.
  • [#Short Chain Fatty Acid] - Exercise increased fecal SCFA concentrations in lean but not obese participants. - These effects were reversed after 6 weeks of ceasing exercise training suggesting that sustainment of exercise is necessary for long-term exercise-induced Gut Microbiota alterations.
  • [1.9
  • [#Fecal Microbiota Transplantation] - #Phocaeicola barnesiae, #Eisenbergiella massiliensis, and #Anaeroplasma abactoclasticum in the gut microbiome as positive contributors to #Muscle strength. - #Ileibacterium valens and #Ethanoligenens harbinense were found to have negative effects on muscle strenght.

References Notes

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