Microbiome & Chronic Diseases

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Clostridia ⇒ Clostridiales {10000119}

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Enhancing CD4(+) T regulatory, Pro-inflamatory


- Mice colonized with Clostridia bacteria had more regulatory T cells, a type of cell that dampens immune responses. The Clostridia mice also produced more of a molecule called IL-22 that strengthens the intestinal lining. (1)

Shared Reference Notes

  • [1.1] [#Colorectal cancer
    - Clostridiales species are significantly reduced in CRC patients compared with healthy controls. - Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even successfully treated CRC as stand-alone therapy. This effect depended on intratumoral infiltration and activation of CD8+ T cells. - Single application of Roseburia intestinalis or Anaerostipes caccae is even more effective than CC4. - The CC4 mix supplementation outperformed anti-PD-1 therapy in mouse models of CRC and melanoma.
  • [1.2] [#Parkinson’s Disease
    PD patient group, the abundance of proinflammatory microbes, such as Clostridiales bacterium NK3B98 and #Ruminococcus sp AM07-15, significantly correlated with decreased fecal levels and increased plasma levels of SCFAs, especially #Propionic acid.
  • [1.3
    - GutAlive maintained extremely #Oxygen sensitive (EOS) populations that were lost in conventional stool containers, and thus viability of species such as as #Akkermansia muciniphila, #Faecalibacterium prausnitzii and a novel member of the Clostridiales order was kept.
  • [1.4
    - a significant decrease of microbiome organisms (Clostridiales, #Bacteroidales, and #Campylobacterales) and mycobiome (#Saccharomycetales and #Pleosporales) following #Circumcision.
  • [1.5] [#Graves’ disease, #Graves’ orbitopathy
    - presence of certain bacteria (Clostridiales) at diagnosis correlated with the persistence of TRAB 200 + days after commencing anti-thyroid drug treatment.
  • [1.6
    - #Fasting > increased microbiome diversity and was specifically associated with upregulation of the Clostridiales order–derived #Lachnospiraceae and #Ruminococcaceae bacterial families. - increased #Lachnospiraceae > #Butyrate

References Notes

  • [1.25

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