Clostridia ⇒ Clostridiales {10000119} Record Keys Parent:Clostridia Definition:Clostridiales Details Initialisation date:2020-09-06 LinksSource Meta Information Rank: Order Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:Enhancing CD4(+) T regulatory , Pro-inflamatory Notes: - Mice colonized with Clostridia bacteria had more regulatory T cells, a type of cell that dampens immune responses. The Clostridia mice also produced more of a molecule called IL-22 that strengthens the intestinal lining. (1)Shared Reference Notes [1.1] [#Colorectal cancer] - Clostridiales species are significantly reduced in CRC patients compared with healthy controls. - Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even successfully treated CRC as stand-alone therapy. This effect depended on intratumoral infiltration and activation of CD8+ T cells. - Single application of Roseburia intestinalis or Anaerostipes caccae is even more effective than CC4. - The CC4 mix supplementation outperformed anti-PD-1 therapy in mouse models of CRC and melanoma. [1.2] [#Parkinson’s Disease] PD patient group, the abundance of proinflammatory microbes, such as Clostridiales bacterium NK3B98 and #Ruminococcus sp AM07-15, significantly correlated with decreased fecal levels and increased plasma levels of SCFAs, especially #Propionic acid. [1.3] - GutAlive maintained extremely #Oxygen sensitive (EOS) populations that were lost in conventional stool containers, and thus viability of species such as as #Akkermansia muciniphila, #Faecalibacterium prausnitzii and a novel member of the Clostridiales order was kept. [1.4] - a significant decrease of microbiome organisms (Clostridiales, #Bacteroidales, and #Campylobacterales) and mycobiome (#Saccharomycetales and #Pleosporales) following #Circumcision. [1.5] [#Graves’ disease, #Graves’ orbitopathy] - presence of certain bacteria (Clostridiales) at diagnosis correlated with the persistence of TRAB 200 + days after commencing anti-thyroid drug treatment. [1.6] - #Fasting > increased microbiome diversity and was specifically associated with upregulation of the Clostridiales order–derived #Lachnospiraceae and #Ruminococcaceae bacterial families. - increased #Lachnospiraceae > #Butyrate [1.7] [#Gender] -male premature #Infants have less rich microbiota with higher numbers of #Enterobacteriales, as compared to female premature #Infants who show higher numbers of Clostridiales [1.8] - Increased mucus production in the intestine is another key feature of type 2 responses to helminth infections,16 and it forms a key interface with bacterial populations. - this mucus-rich environment may favor the expansion of Clostridiales bacteria that can have anti-inflammatory properties during helminth infections. [1.9] [#Short Chain Fatty Acid] [#Aging] - Age-related intestinal dysbiosis is generally characterized by a decrease in short-chain fatty acid producers, for example, Clostridiales, and #Bifidobacterium, and enrichment of pro-inflammatory #Proteobacteria including the opportunistic #Enterobacteriaceae. - the gut microbiome signatures associated with the markers of cellular senescence and inflammatory factors, known as senescence-associated secretory phenotype (SASP) were evaluated. Findings revealed that Clostridiales, #Staphylococcus, and #Lachnospiraceae positively correlated with all of the cellular senescence and inflammatory markers. [#Major depressive disorder] - in MDD > Changes observed in lipoproteins, were consistent with the differential composition of gut microbiota belonging to the order Clostridiales and the phyla #Proteobacteria/Pseudomonadota and #Bacteroidetes/#Bacteroidota. [1.11] [#Irritable bowel syndrome] - IBS patients have increased levels of the bacterial families #Enterobacteriaceae, #Lactobacillaceae, and #Bacteroidales, whereas #Bifidobacterium, #Faecalibacterium, and Clostridiales were decreased compared with healthy controls. [1.12] [#Faecalibacterium prausnitzii] [#Aging] - older subjects with physical #Frailty and #Sarcopenia > Lower abundance of F. prausnitzii, as well as members of the Clostridiales class including #Eubacterium and #Roseburia genera. [1.13] [#Prostate cancer] [#Short Chain Fatty Acid] - #Subdoligranulum, #Lachnobacterium, #Christensenellaceae, #Lachnospira, #Rikenellaceae, #Eggerthella, and #Alistipes are members of the SCFA-producing order clostridiales and were shown to be more prevalent in individuals with high-grade PCA. [1.14] - abundances of #Bacteroidales and Clostridiales decreased, and abundances of #Lactobacillales and #Erysipelotrichaceae taxa increased in #Folate-deficient mice [1.15] [#Clostridium cluster IV, #Clostridium clusters XIVa] [#Butyrate] - The predominant butyrogenic bacterial species, including #Faecalibacterium prausnitzii, #Clostridium spp., #Eubacterium spp., and #Roseburia spp., are from two clusters (#Clostridium clusters IV and XIVa) in the #Firmicutes phylum and the Clostridiales order [1.16] [#Osteoporosis] - genera #DTU089, a Clostridiales bacterium, was generally associated with lower bone density consistently in both of the two cohorts. - #DTU089 is associated with lower protein intake [1.17] [#Cognitive impairment] [#Bacteroides finegoldii, #Blautia wexlerae, #Roseburia faecis] - B. wexlerae, #Dorea longicatena, R. faecis, and A. finegoldii, are Clostridiales > positively associated with cognitive function in children. [1.18] - decreased abundance of Clostridiales bacterium in the stools of #Bladder cancer patients, but increased #Streptococcus and #Escherichia. [1.19] [#Covid-19] [#mRNA vaccine] - high spike IgG levels, with less abundance of bacterial groups belonging to Clostridiales and #Methanobacteriales, such as #Ruminococcaceae #DTU089 and #Methanobrevibacter, respectively. References Notes [1.38]
