Inulin-Type Fructans {50000111} Record Keys Definition:Inulin-Type Fructans Queue:[ ] Details Initialisation date:2019-02-24 Specification: [ ] Meta Information Type:Prebiotic Host: Human Zone:[ ] Notes: - Prebiotics such as inulin-type fructans (ITF) and arabinoxylan-oligosaccharides (AXOS) can be consumed to increase the number of bifidobacteria in the colon. (1) - Except for a bifidogenic effect, ITF and AXOS also have shown to cause a butyrogenic effect in the human colon, i.e., an enhancement of colon butyrate production. Butyrate is an essential metabolite in the human colon, as it is the preferred energy source for the colon epithelial cells, contributes to the maintenance of the gut barrier functions, and has immunomodulatory and anti-inflammatory properties. (1) - The butyrogenic effects of ITF and AXOS are the result of cross-feeding interactions between bifidobacteria and butyrate-producing colon bacteria, such as Faecalibacterium prausnitzii (clostridial cluster IV) and Anaerostipes, Eubacterium, and Roseburia species (clostridial cluster XIVa). (1)Shared Reference Notes [1.1] - #Butyrate production may also be driven by bacteria unable to degrade inulin type fructans, but are capable of consuming #Acetate, producing #Butyrate, and utilising partially degraded carbohydrate from #Bifidobacteria. [1.2] [#CVD, #Obesity] - Addition of ITF to the #Plant-based diet reduced microbial diversity and selectively increased #Bifidobacterium and #Faecalibacterium. -- The change in the latter was significantly associated with higher values of insulin and HOMA-IR and lower HDL #Cholesterol. - The LDL:HDL ratio and the concentrations of IL-10, MCP-1 and TNFα were significantly elevated in the ITF-subgroup.References Notes[ ]
