Disease ⇒ Metabolic syndrome ⇒ Prediabetes {40000332}

Shared Reference Notes

• [1.1] [#High-fat diet] 
  - microbiota protects against development of #Obesity, #Metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. - High-fat, high-#Sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. - Diet-induced loss of protective Th17 cells was mediated by the presence of #Sugar. - Eliminating #Sugar from high-fat diets protected mice from #Obesity and #Metabolic syndrome in a manner dependent on commensal-specific Th17 cells. - #Sugar and ILC3 promoted outgrowth of #Faecalibaculum rodentium that displaced Th17-inducing microbiota.
• [1.2] 
  - patients with prediabetes had significantly lower levels of #Butyrate bacteria than healthy people.

References Notes