Disease ⇒ Metabolic syndrome ⇒ Prediabetes {40000332} Record Keys Type:Disease Parent:Metabolic syndrome Definition:Prediabetes Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10065542 MedDra Level:llt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#High Fat Diet] - microbiota protects against development of #Obesity, #Metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. - High-fat, high-#Sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. - Diet-induced loss of protective Th17 cells was mediated by the presence of #Sugar. - Eliminating #Sugar from high-fat diets protected mice from #Obesity and #Metabolic syndrome in a manner dependent on commensal-specific Th17 cells. - #Sugar and ILC3 promoted outgrowth of #Faecalibaculum rodentium that displaced Th17-inducing microbiota. [1.2] - patients with prediabetes had significantly lower levels of #Butyrate bacteria than healthy people. [1.3] [#Diabetes Type 2] [#Ruminococcus gnavus] - R. gnavus showed significantly higher abundance in patients with type 2 diabetes mellitus (T2DM) and prediabetes (PreDM). [1.4] [#Short Chain Fatty Acid] - adults with prediabetes > #Metformin > increased the abundance of GM SCFA-producing bacteria M (#Fusicatenibacter and #Blautia) - adults with prediabetes > linagliptin/#Metformin > Roseburia, Bifidobacterium, and [Eubacterium] hallii group.References Notes[ ]
