Bifidobacterium ⇒ Bifidobacterium longum {10000149} Record Keys Parent:Bifidobacterium Definition:Bifidobacterium longum Details Initialisation date:2020-09-06 LinksSource Meta Information Rank: Species Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:Immunomodulation, Anti-cancer Notes: [ ]Shared Reference Notes [1.1] B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. [1.2] [#Infant colic] [1.3] [#Selenium] [#Food Minerals] - Se-enriched Bifidobacterium longum >Biotransformation of inorganic Se into bioactive organic Se > High bioaccessibility of selenomethionine and 98% enteric absorbtion [1.4] - #Protein powder consumption > decrease in #Lachnospiraceae, #Roseburia, #Blautia, Synergistales, #Coprococcus, #Lactobacillales, Bacilli, Bifidobacterium longum and #Firmicutes. - #Protein powder consumption > higher abundance of #Bacteroidetes. [1.5] [#Pediococcus pentosaceus] [#Probiotic] [1.6] - Severe Covid > higher abundance of four microbial species (i.e., #Burkholderia contaminans, #Bacteroides nordii, Bifidobacterium longum, and #Blautia sp. CAG 257), six microbial pathways (e.g., glycolysis and fermentation), and 10 virulence genes > further associated with host immune response. - The abundance of Bu. contaminans > associated with higher levels of inflammation biomarkers and lower levels of immune cells. - human-origin proteins identified from both blood and fecal samples suggested gut barrier dysfunction in #Covid-19 patients. - The circulating levels of #Lipopolysaccharide-binding protein increased in patients with severe illness > associated with circulating inflammation biomarkers and immune cells. - proteins of disease-related bacteria (e.g., B. longum) were detectable in blood samples from patients. [1.7] [#Human milk oligosaccharides] [#Human breast milk] - breast fed babies #Bifidobacterium spp. is typically high, than in formula fed babies because #Bifidobacterium longum utilizes fucosylated oligosaccharides which is present in mother’s milk. [1.8] [#Multiple Sclerosis] - six species are significantly lower in abundance in MS patients than in controls, three of which have known immunomodulatory properties (Bifidobacterium longum, #Clostridium leptum, #Faecalibacterium prausnitzii) [1.9] [#Infants] - B. longum abundance was inversely correlated with #Inosine, a purine metabolite with immunoregulatory properties [#Bipolar disorder, #Major depressive disorder] [#Bifidobacterium infantis] - the abundance of #Fusobacteriaceae, #Escherichia blattae DSM 4481 and #Klebsiella oxytoca were significantly augmented, whereas the Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 was significantly reduced in BD group compared with MDD group [1.11] [#Bifidobacterium infantis] [#Human milk lipids] [#Human breast milk] - #Gangliosides are not antagonistic to all gastrointestinal microorganisms. - Bifidobacterium can grow in the presence of GM-3 and GD-3 while simultaneously lowering ganglioside levels in vitro. - #Bifidobacterium bifidum is very efficient in removing GD-3 by employing extracellular mechanisms, while Bifidobacterium longum subsp. infantis degrades GM-3 intracellularly, with overall lower glycosidase activity. [#Bifidobacterium infantis] - #Phosphatidylcholine is a major membrane-forming phospholipid in eukaryotes, with an estimated presence of 15% in the bacterial kingdom. - #Phosphatidylcholine exert a prebiotic function on B. longum subsp. infantis, which, by translating the compound to 1,2-sn-diacylglycerols, affects the regulation of colonic mucus production. [1.12] [#Lactobacillus helveticus] - consum of a mix of psychobiotics (L. helveticus and B. longum) exhibited less #Anxiety and #Depression than controls. [#Depression] [#Bifidobacterium animalis lactis, #Bifidobacterium bifidum, #Lactobacillus acidophilus] [#humanized Galactooligosaccharides] [#Combination of probiotics and polyphenol-rich prebiotics] - patients were administered a synbiotic containing L. acidophilus, B. bifidum, B. lactis, and B. longum with the prebiotics FOS, GOS and #Inulin. In a subset of patients with depressive symptoms, the synbiotic significantly reduced the depressive score compared to both the #Probiotic-alone and placebo groups, which correlated to an increase in #BDNF serum levels. [1.13] [#Antibiotic Therapy] - Bifidobacterium longum abundance was found to be associated with germinal center frequency. When re-introduced to antibiotic-exposed mice, B. longum partially rescued the immunological deficits. [1.14] [#Bacteroides vulgatus] [#carrot-derived rhamnogalacturonan I] [#Carrot] - cRG-I supplementation (already at an HED of 0.3 g/d) lowered interpersonal compositional differences due to the selective stimulation of taxa that were consistently present among human adults, including OTUs related to #Bacteroides dorei/vulgatus and Bifidobacterium longum (suspected keystone species), #Bacteroides thetaiotaomicron, #Bifidobacterium adolescentis and #Butyrate-producing taxa such as #Blautia sp., #Anaerobutyricum hallii, and #Faecalibacterium prausnitzii. [1.15] [#Plant-based diet] - #Plant protein intake correlates more closely with enrichment of some members of the #Bifidobacterium genus (e.g., B. longum) [1.16] - Bifidobacterium longum, have been observed to downregulate #IL-6 in fetal human enterocytes in vitro [1.17] - #Bacteroides fragilis and #Prevotella copri (#Bacteroidetes), Bifidobacterium longum and #Collinsella aerofaciens (#Actinobacteria), and #Helicobacter pylori (#Proteobacteria) can produce #Vitamin B6 as they have these biosynthetic mechanisms [#Bifidobacterium infantis, #Clostridioides difficile, #Kingella denitrificans, #Propionibacterium freudenreichii] - #Vitamin B12 producer are > #Pseudomonas denitrificans, #Bacillus megaterium, and Propionibacterium freudenreichi, #Bacteroides fragilis, #Prevotella copri, #Clostridium difficile, #Faecalibacterium prausnitzii, #Ruminococcus lactaris, #Bifidobacterium animalis, B.infantis, B.longum, and #Fusobacterium varium [#Bifidobacterium adolescentis, #Bifidobacterium bifidum, #Bifidobacterium breve, #Bifidobacterium infantis] - #Bifidobacterium species are categorized on the basis of their #Folate-producing ability: high #Folate producers—#Bifidobacterium bifidum and B. longum subsp. Infantis, and low #Folate producers—B. breve, B. longum subsp. longum, and B. adolescentis. [1.18] [#Bifidobacterium infantis] [#Para-cresol] - Antibitic resulted dysbiosis > Application of synbiotic Bifidobacterium longum subspecies infantis (B. infantis), and #Human milk oligosaccharides (HMOs) > - increases in #Lactate-consuming #Veillonella, faster #Acetate recovery, and changes in #Indolelactate and p-cresol #Sulfate, metabolites that impact host inflammatory status. - #Veillonella co-cultured in vitro and in vivo with B. infantis and HMO converts #Lactate produced by B. infantis to #Propionate, an important mediator of host physiology. [1.19] - the change in diet from an #Isoflavone diet to a #Phytoestrogen-free diet significantly reduced the abundance of Bifidobacterium species, specifically #Bifidobacterium adolescentis and Bifidobacterium longum [#Non-Hodgkin lymphoma] - in Lymphoma > higher pre-treatment Bifidobacterium longum and microbiome-encoded #Peptidoglycan biosynthesis was linked to better survival outcomes after #CAR T-cell therapy. [1.21] [#Bifidobacterium adolescentis] - the two species of Bifidobacterium that were significantly increased by the #Cranberry extract, namely B. adolescentis and B. longum, are known to be great degrader of xylo- and #Arabinoxylan-oligosaccharides [1.22] [#Bifidobacterium adolescentis, #Bifidobacterium catenulatum] [#Adult, #Aging] - The most abundant bifidobacterial species found in adults are B. adolescentis, B. catenulatum, and B. longum. - It has been observed that in later stages of life, with an increase in age, levels of #Bifidobacterium further decrease. [#Gastric carcinoma, #Peptic ulcer] [#Bifidobacterium adolescentis, #Bifidobacterium bifidum, #Bifidobacterium breve, #Bifidobacterium pseudocatenulatum, #Chloracidobacterium thermophilum B, #Helicobacter pylori, #Limosilactobacillus (Lactobacillus) reuteri] - H. pylori infection alone is not sufficient to develop severe gastric abnormalities such as gastric cancer and gastric ulcers. - A lower abundance of gut resident #Bifidobacterium genus with specific strains ( B. adolescentis, B. bifidum, B. breve, B. longum, B. moukalabense, B. pseudocatenulatum, and B. reuteri.) plays a significant role in developing severe gastric malignancy. [1.23] [#Chloracidobacterium thermophilum B] - #Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 can inhibit NF-κB pathway to inhibit inflammatory response [1.24] [#Roseburia intestinalis] [#Homovanillic acid] - R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation. [#Roseburia intestinalis] [#Homovanillic acid] - Administering HVA, B. longum, or R. intestinalis to mouse models with chronic unpredictable mild stress (CUMS) and corticosterone (CORT)-induced #Depression significantly improved depressive symptoms. - HVA inhibited synaptic autophagic death by preventing excessive degradation of microtubule-associated protein 1 light chain 3 (LC3) and SQSTM1/p62 proteins, protecting hippocampal neurons’ presynaptic membrane. [1.25] [#Short Chain Fatty Acid] - Dietary rhamnogalacturonan-I obtained by enzymatic treatment of #Carrot pomace has shown #Prebiotic properties. - cRG-I was degraded rapidly in the proximal colon compartment and fermentation became quicker and more complete during three weeks of repeated supplementation. - arabinan sidechains were utilized before the RG-I backbone, which correlated with an increase in Bifidobacterium longum absolute abundance over the three weeks period. - Donor specific production of all SCFA increased over time with a general trend of higher levels of #Acetate and #Propionate than #Butyrate. [1.26] - antiviral vaccination > ten microbial features, like genus #Collinsella, species Bifidobacterium longum, and the biosynthesis of L-#Alanine have shown the capacity to regulate multiple IgG levels with consistent direction (rise or fall). [1.27] [#Bifidobacterium adolescentis, #Clostridium cluster I] [#Rhamnogalacturonan-I] - cRG-I supplementation has a bifidogenic effect in healthy adults (B. adolescentis and B. longum). [1.28] - negative association between the Bifidobacterium longum group and the Childhood #Autism Rating Scale, as well as a negative association between the #Streptococcus salivarus group and the Social Responsiveness Scale (SRS) within the ASD group. References Notes (1) [1.51]
