Disease ⇒ Helicobacter pylori infection {40000300} Record Keys Type:Disease Parent:[ ] Definition:Helicobacter pylori infection Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10054263 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Alzheimer’s disease] - 11% increase in the risk of AD associated with exposure to CAHPI (clinically apparent #Helicobacter pylori infection) among subjects aged at least 50 years. - The increase in the risk of AD reached a peak of 24% roughly a decade after the onset of CAHPI > statistical significance roughly 8 years following CAHPI onset, peaked 2 years later, and decreased afterwards. - Helicobacter pylori infection > structural damage in gastric mucosa caused by chronic HP infection could affect the absorption of #Vitamin B12 and #Iron, a deficit of which is associated with #Dementia. [#Helicobacter pylori] - HP can access the brain via the oral-nasal-olfactory axis or by infected circulating monocytes through a disrupted blood-brain-barrier > potentially leading to neuroinflammation, neuronal damage, and neurodegeneration.References Notes[ ]
