Disease ⇒ Reactive arthritis {40000346} Record Keys Type:Disease Parent:[ ] Definition:Reactive arthritis Details Initialisation date:[ ] Other Terms:RA Meta Information MedDra ID:10003267 MedDra Level:llt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Inflamatory bowel disease] - HLA-B27 spondyloarthropathies (SpA) > #Ankylosing spondylitis, reactive arthritis, #Psoriatic Arthritis, #Juvenile idiopathic arthritis, inflammatory bowel disease, #Acute anterior uveitis, and undifferentiated SpA > segmented filamentous bacteria (SFB) have been illustrated to be a common culprit in initiating an arthritogenic reaction. - The Th17 response, induced in the mesenteric lymph nodes by dendritic cells, in such patients specifically targets SFB, resulting in a breach in the mucosal barrier. - This is thought to result from cross-reactivity between HLA-B27 and pathogenic surface antigens. - Other enteric gram-negative pathogens, which mimic HLA-B27, associated with SpA and uveitis include #Shigella, #Chlamydia and #Yersinia [1.2] [#Rheumatoid Arthritis] [#Prevotella nigrescens] - In a mouse study, P. nigrescens induced #Periodontal disease, resulting in early-onset severe experimental arthritis [1.3] [#Collagen-induced arthritis ] - IAA, #5-Hydroxytryptophan (5-HTP), and 5-HIAA ameliorate arthritis severity in proteoglycan-induced #Spondyloarthritis. CIA, and antigen-induced arthritis, respectively. - #Indole induces pathogenic antibody formation through class switching to IgG2b as well as decreased antibody sialyation that enhances complement fixation, and that these changes may occur through the #IL-23/Th17 axis.References Notes[ ]
